{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T20:45:17Z","timestamp":1785703517367,"version":"3.56.0"},"reference-count":18,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The American Surgeon\u2122"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intraoperative radiation therapy (IORT) is an accepted alternative to whole-breast irradiation for select patients undergoing breast-conserving surgery. While oncologic and cosmetic outcomes have been well described, longitudinal psychosocial outcomes and their relationship to cosmetic recovery remain incompletely characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a prospective single-center cohort study of women with early-stage invasive ductal carcinoma undergoing lumpectomy with IORT between 2019 and 2025. Participants completed the externally validated Functional Assessment of Cancer Therapy\u2013Breast (FACT-B version 4) questionnaire preoperatively and at 6, 12, and 24\u00a0months postoperatively. Cosmetic outcomes were independently assessed by both patients and surgeons. Associations between scar appearance and well-being domains were evaluated using non-parametric correlation analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      94 patients underwent IORT, with 88 (92.6%) completing at least one postoperative survey. Overall quality of life scores remained stable over time, with a modest improvement in emotional well-being at 12\u00a0months (mean change +1.68, 95% CI 0.45-2.91). No statistically significant changes were observed in physical, social, or functional domains. Patient-reported scar scores demonstrated transient worsening at 6\u00a0months with return toward baseline by 12\u00a0months, while provider-rated scar scores improved over time. At 6\u00a0months, worse provider-rated scar appearance was associated with lower physical (r = \u22120.403,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.050) and social well-being (r = \u22120.441,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.033).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patient-reported quality of life remained stable following IORT, with modest improvement in emotional well-being. Early provider-rated cosmetic appearance demonstrated meaningful associations with physical and social well-being during survivorship, suggesting clinician-assessed cosmetic recovery may provide additional insights into postoperative recovery beyond self-assessment. These findings are descriptive and hypothesis-generating and warrant confirmation in comparative studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00031348261472846","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T04:49:31Z","timestamp":1785386971000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal Patient-Reported Outcomes and Early Provider-Rated Cosmetic Associations Following Intraoperative Radiation Therapy in Early-Stage Breast Cancer"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5820-7287","authenticated-orcid":false,"given":"Maria","family":"Vazquez de Santos","sequence":"first","affiliation":[{"name":"Atrium Health Navicent Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trisha","family":"Weber","sequence":"additional","affiliation":[{"name":"Atrium Health Navicent Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1594-9202","authenticated-orcid":false,"given":"Faith","family":"Rand","sequence":"additional","affiliation":[{"name":"Atrium Health Navicent Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Montgomery","sequence":"additional","affiliation":[{"name":"Atrium Health Navicent Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7090-6315","authenticated-orcid":false,"given":"Paul","family":"Dale","sequence":"additional","affiliation":[{"name":"Atrium Health Navicent Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.13574"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2018.01.001"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2022.10.077"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/0003134820956351"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70497-2"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-018-6614-3"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.14128"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2007.06.018"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60837-9"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61950-9"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m2836"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/00031348211047499"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.13708"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12893-021-01427-5"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers18040699"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.14128"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2025.15092"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2025.09.029"}],"container-title":["The American Surgeon\u2122"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00031348261472846","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00031348261472846","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00031348261472846","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T19:45:38Z","timestamp":1785699938000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00031348261472846"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,29]]},"references-count":18,"alternative-id":["10.1177\/00031348261472846"],"URL":"https:\/\/doi.org\/10.1177\/00031348261472846","relation":{},"ISSN":["0003-1348","1555-9823"],"issn-type":[{"value":"0003-1348","type":"print"},{"value":"1555-9823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,29]]},"article-number":"00031348261472846"}}