{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:51:38Z","timestamp":1791568298935,"version":"4.3.4"},"reference-count":17,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The American Surgeon\u2122"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Small intestinal neuroendocrine tumors (SiNETs) are rare tumors with propensity to cause bulky fibrotic mesenteric masses by hematogenous and lymphatic invasion. They exhibit variable oncological behavior and reliable prognostic markers remain elusive. The 8\n                      <jats:sup>th<\/jats:sup>\n                      edition American Joint Commission on Cancer introduced mesenteric mass \u22652\u00a0cm to improve prognostication. The clinical utility in prognostication remains unknown. We reviewed outcomes of resected SiNETs to determine if computed tomography (CT) size is associated with oncological outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective review of resected SiNET patients at two tertiary centers with evaluable preoperative CT scans. Measured the largest diameter of the mesenteric mass and the cutoff of 2\u00a0cm used to correlate with oncological outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventy-three patients operated for SiNET with preoperative CT were included. The largest mesenteric mass was &lt;2\u00a0cm in 28 and \u22652\u00a0cm in 45 patients. Cohorts were similar in demographic and clinical characteristics. Median follow-up was 47\u00a0months. Overall survival (OS) and progression free survival (PFS) were similar. No significant differences in estimated mean OS (136 vs 139\u00a0months,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.981) or median PFS (90 vs 71\u00a0months,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.126) for the &lt;2\u00a0cm and &gt;2\u00a0cm cohorts, respectively. Univariable analysis failed to show an association between mesenteric size as a continuous variable, and at the \u22652 cmcutoff. Age, cardiac comorbidities, and palliative intent surgery were the only factors that correlated with survival.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Mesenteric mass size on preoperative CT was not correlated with oncological outcomes and by itself showed little utility in preoperative decision-making.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00031348261495997","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:28:23Z","timestamp":1791415703000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Size Under Scrutiny: Preoperative Imaging Size of Mesenteric Deposits Does Not Predict Oncological Outcomes in Small Intestinal Neuroendocrine Tumors"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9591-2939","authenticated-orcid":false,"given":"Adam","family":"Goldstein","sequence":"first","affiliation":[{"name":"Wolfson Medical Center"},{"name":"Tel Aviv University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haggi","family":"Mazeh","sequence":"additional","affiliation":[{"name":"Hadassah Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Kushnir","sequence":"additional","affiliation":[{"name":"Hadassah Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naheel","family":"Mahajna","sequence":"additional","affiliation":[{"name":"Wolfson Medical Center"},{"name":"Tel Aviv University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaara","family":"Gutman","sequence":"additional","affiliation":[{"name":"Tel Aviv University"},{"name":"Sheba Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehonatan","family":"Bar Moshe","sequence":"additional","affiliation":[{"name":"Hadassah Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amram","family":"Kupietzky","sequence":"additional","affiliation":[{"name":"Hadassah Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orit","family":"Twito","sequence":"additional","affiliation":[{"name":"Tel Aviv University"},{"name":"Wolfson Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilan","family":"Edri","sequence":"additional","affiliation":[{"name":"Wolfson Medical Center"},{"name":"Tel Aviv University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimrit","family":"Eliyahu","sequence":"additional","affiliation":[{"name":"Wolfson Medical Center"},{"name":"Tel Aviv University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mordechai","family":"Shimonov","sequence":"additional","affiliation":[{"name":"Wolfson Medical Center"},{"name":"Tel Aviv University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6629-453X","authenticated-orcid":false,"given":"Shachar","family":"Laks","sequence":"additional","affiliation":[{"name":"Wolfson Medical Center"},{"name":"Tel Aviv University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.0589"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2025.15798"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000000846"},{"key":"e_1_3_5_5_2","first-page":"206350","article-title":"Incidence and survival of patients with small intestinal neuroendocrine tumors in a Danish NET center","volume":"2012","author":"Brehm Hoej L","year":"2012","unstructured":"Brehm Hoej L, Marie Nykj\u00e6r K, Gronbaek H. Incidence and survival of patients with small intestinal neuroendocrine tumors in a Danish NET center. Sci World J. 2012;2012:206350.","journal-title":"Sci World J"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-011-1296-z"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2023-0169-OA"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000000476"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000491017"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-017-3524-9"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.44.5924"},{"key":"e_1_3_5_12_2","volume-title":"AJCC cancer staging manual","author":"Byrd DR","year":"2017","unstructured":"Byrd DR, Brookland RK, Washington MK, et al. AJCC cancer staging manual, Amin MB, Edge SB, Greene FL, eds. 1024. New York: Springer; 2017."},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-018-6511-9"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2021.03.036"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2018.3865"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-018-0075-x"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.25727"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2026.102414"}],"container-title":["The American Surgeon\u2122"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00031348261495997","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00031348261495997","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00031348261495997","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:04:49Z","timestamp":1791565489000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00031348261495997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,7]]},"references-count":17,"alternative-id":["10.1177\/00031348261495997"],"URL":"https:\/\/doi.org\/10.1177\/00031348261495997","relation":{},"ISSN":["0003-1348","1555-9823"],"issn-type":[{"value":"0003-1348","type":"print"},{"value":"1555-9823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,7]]},"article-number":"00031348261495997"}}