{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:09:31Z","timestamp":1777399771950,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2000,11,1]],"date-time":"2000-11-01T00:00:00Z","timestamp":973036800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angiology"],"published-print":{"date-parts":[[2000,11]]},"abstract":"<jats:p>This study investigated the effect of the angiotensin-converting enzyme (ACE) inhibitor perindopril on left ventricular (LV) remodeling and cardiac function in rats with aortic regurgitation (AR). Twenty male Sprague-Dawley rats in which AR was produced by closed-chest aortic valve puncture were divided into untreated and perindopril-treated (5 mg\/kg\/day) rats. Ten control rats were sham-operated. Blood pressure, body weight, and echocardiographic recordings were followed every 2 weeks for a period of 12 weeks. LV dimension (LVD) and fractional shortening (FS) were calculated. The heart was finally excised for weight, hydroxyproline measurements, and histopathology. At 12 weeks, end- diastolic LVD increased in untreated rats (10.8 \u00b10.2 mm) but did not dilate in treated rats (9.6 \u00b1 0.3 mm, p &lt; 0.01 vs untreated rats). FS decreased from 6 weeks in untreated rats (27.3 \u00b10.9% at 12 weeks), but did not change in treated rats (33.8 \u00b10.5%, p &lt; 0.001). The ratio of LV weight to body weight in untreated rats (2.62 \u00b10.11 mg\/g, p &lt; 0.05) was higher than in sham-operated rats (1.52 \u00b10.02 mg\/g) and than in treated rats (1.95 \u00b10.07 mg\/g). Interstitial collagen accumulation histopathologically increased in untreated rats and was inhibited in treated rats. LV collagen of untreated rats (1.46 \u00b10.08 mg\/100 mg, p = 0.03) was higher than those of treated (1.08 \u00b10.09 mg\/100 mg) and sham-operated rats (1.06 \u00b10.14 mg\/100 mg). Perindopril inhibited LV remodeling induced by volume overload and preserved LV function in AR rats.<\/jats:p>","DOI":"10.1177\/000331970005101107","type":"journal-article","created":{"date-parts":[[2008,7,28]],"date-time":"2008-07-28T17:57:07Z","timestamp":1217267827000},"page":"943-952","source":"Crossref","is-referenced-by-count":5,"title":["Effects of Perindopril on Left Ventricular Remodeling and Aortic Regurgitation in Rats Assessed by Echocardiography"],"prefix":"10.1177","volume":"51","author":[{"given":"Kazushi","family":"Murakami","sequence":"first","affiliation":[{"name":"Second Department of Internal Medicine, Kagawa Medical University, Kagawa, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsufumi","family":"Mizushige","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, Kagawa Medical University, Kagawa, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahisa","family":"Noma","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, Kagawa Medical University, Kagawa, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoji","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Kagawa Medical University, Kagawa, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Kagawa Medical University, Kagawa, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirohide","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, Kagawa Medical University, Kagawa, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2000,11,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1159\/000006827"},{"key":"atypb2","first-page":"H556","volume":"267","author":"Magid NM","year":"1994","journal-title":"Am J Physiol"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.6.525"},{"key":"atypb4","doi-asserted-by":"crossref","first-page":"H226","DOI":"10.1152\/ajpcell.1992.263.1.C226","volume":"263","author":"Magid NM","year":"1992","journal-title":"Am J Physiol"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199209033271001"},{"key":"atypb6","first-page":"197","volume":"3","author":"Wisenbaugh T.","year":"1994","journal-title":"J Heart Valve Dis"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.86.5.1566"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.36.91"},{"key":"atypb9","first-page":"419","volume":"46","author":"Simko F.","year":"1997","journal-title":"Physiol Res"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/0160-5402(89)90004-1"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.1.345"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1993.74.5.2598"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(67)90167-2"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1038\/204347a0"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/24.11.946"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.5.2273"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199603000-00006"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119360"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.83.5.1771"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1016\/0895-7061(95)00120-E"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)90868-0"}],"container-title":["Angiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000331970005101107","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000331970005101107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:15:44Z","timestamp":1777371344000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000331970005101107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,11]]},"references-count":21,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2000,11]]}},"alternative-id":["10.1177\/000331970005101107"],"URL":"https:\/\/doi.org\/10.1177\/000331970005101107","relation":{},"ISSN":["0003-3197","1940-1574"],"issn-type":[{"value":"0003-3197","type":"print"},{"value":"1940-1574","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,11]]}}}