{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:12:41Z","timestamp":1777399961800,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2001,12,1]],"date-time":"2001-12-01T00:00:00Z","timestamp":1007164800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angiology"],"published-print":{"date-parts":[[2001,12]]},"abstract":"<jats:p>A rabbit model was used to examine the effects of tissue plasminogen activator (tPA) on development of intimal hyperplasia following balloon injury. Thirty-two hereditary hypercho lesterolemic (KHC) rabbits underwent percutaneous transluminal coronary artery balloon catheterization and injury to the common iliac artery, after which they were divided into four groups: untreated (control); Dispatch catheterized-30 minutes local saline delivery [D(+)- tPA(-)]; D(+)-30 minutes local tPA delivery (0.6 mg\/kg) [D(+)-tPA(30 min)]; and D(+)-30 minutes local tPA + 3 days intravenous infusion (0.6 mg\/kg\/24 h) [(D(+)-tPA(30 min + 3 d)]. Twenty-eight days later, the intimal cross-sectional areas of all three Dispatch catheterized groups were significantly smaller than those of control groups, as were the intimal\/medial area ratios. Moreover, the intima\/media ratios of the D(+)-tPA(30 min + 3 d) group were significantly smaller than those of the D(+)-tPA(-) group. Thus, local delivery of tPA via Dispatch catheters followed by continuous intravenous infusion of tPA for 3 days prevented intimal hyperplasia after angioplasty.<\/jats:p>","DOI":"10.1177\/000331970105201203","type":"journal-article","created":{"date-parts":[[2008,7,28]],"date-time":"2008-07-28T17:57:07Z","timestamp":1217267827000},"page":"819-825","source":"Crossref","is-referenced-by-count":5,"title":["tPA via Infusion Catheters Followed by Continuous IV Infusion for 3 Days Prevents Intimal Hyperplasia After Balloon Injury"],"prefix":"10.1177","volume":"52","author":[{"given":"Ken","family":"Kanamasa","sequence":"first","affiliation":[{"name":"Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshikazu","family":"Inoue","sequence":"additional","affiliation":[{"name":"Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narutaka","family":"Otani","sequence":"additional","affiliation":[{"name":"Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norikatsu","family":"Naito","sequence":"additional","affiliation":[{"name":"Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Morii","sequence":"additional","affiliation":[{"name":"Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsugu","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norihiro","family":"Ishida","sequence":"additional","affiliation":[{"name":"Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kinji","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2001,12,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.73.4.710"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.77.2.361"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(85)90231-5"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(89)90611-X"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(10)80196-2"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90389-5"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1253\/jcj.60.889"},{"key":"atypb8","first-page":"385","volume":"45","author":"Kurosawa T.","year":"1995","journal-title":"Lab Anim Sci"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.67.3.651"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.73.4.671"},{"key":"atypb11","doi-asserted-by":"crossref","unstructured":"Jackson CL, Reidy MA: The role of plasminogen activation in smooth muscle cell migration after arterial injury. 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