{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:16:18Z","timestamp":1777400178960,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2002,11,1]],"date-time":"2002-11-01T00:00:00Z","timestamp":1036108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angiology"],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:p>\n                    The purposes of this study were to assess the occurrence of euthyroid sick syndrome in patients with acute myocardial infarction (AMI) or unstable angina (UA), and the relationship with \u03b2-blocker or thrombolytic therapy. Plasma triiodothyronine (T3), reverse T3 (rT\n                    <jats:sub>3<\/jats:sub>\n                    ), free T\n                    <jats:sub>3<\/jats:sub>\n                    (FT\n                    <jats:sub>3<\/jats:sub>\n                    ), thyroxine (T\n                    <jats:sub>4<\/jats:sub>\n                    ), free T\n                    <jats:sub>4<\/jats:sub>\n                    (FT4), thyroid-stimulating hormone (TSH), thyroxine-binding globulin (TBG), and albumin (ALB) levels were determined in 95 patients (59 males, 36 females, aged 58.4 \u00b19) with AMI and 19 patients (13 males, 6 females aged 54.7 \u00b1 12.3) with UA for 5 consecutive days from the onset of the acute syndrome and 1 month later. Patients were divided according to \u03b2-blocker therapy and thrombolytic therapy. There was a significant T\n                    <jats:sub>3<\/jats:sub>\n                    decrease and rT\n                    <jats:sub>3<\/jats:sub>\n                    increase in all patients during the first 5 days following admission (p &lt; 0.05). FT\n                    <jats:sub>3<\/jats:sub>\n                    and FT4 remained unchanged during the study. In patients with complicated infarctions, the rT\n                    <jats:sub>3<\/jats:sub>\n                    increase and the T\n                    <jats:sub>3<\/jats:sub>\n                    decrease were significantly greater compared to those with uncom plicated infarctions (p &lt; 0.03). TSH, T\n                    <jats:sub>4<\/jats:sub>\n                    , TBG, and ALB were significantly (p&lt;0.05) decreased only in complicated infarctions. No differences were observed between patients with or without thrombolysis or patients with or without \u03b2-blocker treatment. The apparent decrease in T\n                    <jats:sub>3<\/jats:sub>\n                    , the increase in rT\n                    <jats:sub>3<\/jats:sub>\n                    levels and the decreased TSH and T\n                    <jats:sub>4<\/jats:sub>\n                    levels, show clearly that the euthyroid sick syndrome (low T3) occurs not only in AMI but also in UA. In addition, these hormonal changes are not affected by \u03b2-blocker therapy and thrombolysis does not influence the occurrence of the syndrome. The degree of T\n                    <jats:sub>3<\/jats:sub>\n                    decrease is proportional to the severity of cardiac damage and may have a possible prognostic value.\n                  <\/jats:p>","DOI":"10.1177\/000331970205300611","type":"journal-article","created":{"date-parts":[[2008,7,28]],"date-time":"2008-07-28T17:57:07Z","timestamp":1217267827000},"page":"699-707","source":"Crossref","is-referenced-by-count":24,"title":["Euthyroid Sick Syndrome in Acute Ischemic Syndromes"],"prefix":"10.1177","volume":"53","author":[{"given":"H.N.","family":"Pavlou","sequence":"first","affiliation":[{"name":"Second Department of Cardiology, St Andreas Patras State Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.A.","family":"Kliridis","sequence":"additional","affiliation":[{"name":"Second Department of Cardiology, St Andreas Patras State Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.A.","family":"Panagiotopoulos","sequence":"additional","affiliation":[{"name":"Second Department of Cardiology, St Andreas Patras State Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.P.","family":"Goritsas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Patras Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.J.","family":"Vassilakos","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University of Patras Medical School, Patras, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2002,11,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-41-6-1043"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-41-5-911"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1530\/acta.0.0870080"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108456"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1981.tb00622.x"},{"key":"atypb6","volume-title":"WHO ischaemic heart disease register","year":"1971"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(67)90023-9"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1530\/acta.0.0940341"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1977226864"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1530\/acta.0.1050190"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1007\/BF00541923"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1978.tb00819.x"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1977.tb15698.x"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(90)90531-H"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(90)90462-X"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1993.tb02401.x"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199512073332302"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)34281-3"},{"key":"atypb19","first-page":"166","volume":"284","author":"Baranetsky NG","year":"1986","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-71-1-98"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1996.6.79"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/44.5.1002"}],"container-title":["Angiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000331970205300611","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000331970205300611","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:17:13Z","timestamp":1777371433000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000331970205300611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,11]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2002,11]]}},"alternative-id":["10.1177\/000331970205300611"],"URL":"https:\/\/doi.org\/10.1177\/000331970205300611","relation":{},"ISSN":["0003-3197","1940-1574"],"issn-type":[{"value":"0003-3197","type":"print"},{"value":"1940-1574","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,11]]}}}