{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:16:45Z","timestamp":1777400205484,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angiology"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:p>Factor V Leiden mutation has emerged as one of the leading abnormalities in inherited blood coagulation disorders, resulting in a markedly increased risk for deep leg vein thrombosis. A 24- year-old woman presented with acute onset of critical ischemia of her left thumb and index finger. Intraarterial angiography revealed an embolus in the distal radial artery and a thrombotic occlusion of the digital artery of the thumb and index finger. Immediate therapy encompassed a selective surgical embolectomy of the distal radial artery followed by a local intraarterial lysis that was continued for 3 days. Additionally, therapeutic anticoagulation and vasodilating drugs (prostaglandin E) were administered. Within 2 days, capillary refill reappeared and the initial loss of sensory function at the tip of the thumb and index finger diminished. A screening test for thrombophilic disorders led to the diagnosis of a heterozygous mutation of factor V (Leiden mutation). Arterial thromboembolic events of factor V Leiden mutation are rare and have to date been described only in the supraaortic and coronary circulation. Therefore, the arterial embolism to the left hand presented in this report constitutes a rarity that could be successfully salvaged by the combined use of a vascular surgical procedure and intensified medical management.<\/jats:p>","DOI":"10.1177\/000331970305400117","type":"journal-article","created":{"date-parts":[[2008,7,28]],"date-time":"2008-07-28T17:57:07Z","timestamp":1217267827000},"page":"125-130","source":"Crossref","is-referenced-by-count":13,"title":["Arterial Embolism to the Upper Extremity in a Patient with Factor V Leiden Mutation (APC Resistance)"],"prefix":"10.1177","volume":"54","author":[{"given":"B.","family":"Dorweiler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Neufang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Kasper-Koenig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Schinzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Schmiedt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Oelert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2003,1,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.3.1004"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1038\/369064a0"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199402243300801"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92939-4"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92940-8"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1650638"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-127-10-199711150-00007"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(97)70348-3"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.7.2353"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)90626-6"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(05)80034-5"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199504063321403"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(98)00161-5"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)80832-3"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.175.2.2326466"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1007\/BF02133407"}],"container-title":["Angiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000331970305400117","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000331970305400117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:17:19Z","timestamp":1777371439000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000331970305400117"}},"subtitle":["A Case Report and Review of the Literature"],"short-title":[],"issued":{"date-parts":[[2003,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,1]]}},"alternative-id":["10.1177\/000331970305400117"],"URL":"https:\/\/doi.org\/10.1177\/000331970305400117","relation":{},"ISSN":["0003-3197","1940-1574"],"issn-type":[{"value":"0003-3197","type":"print"},{"value":"1940-1574","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,1]]}}}