{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:50:07Z","timestamp":1791899407024,"version":"4.3.4"},"reference-count":41,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angiology"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:p>The clinical significance and subsequent management of the various types of coronary artery anomalies (CAAs) are different, as is the relationship to sudden death, coronary artery disease, and myocardial ischemia. A practical global classification based on clinical significance has not yet been proposed. This retrospective study was aimed at evaluating the current clinical significance of CAAs and the effectiveness of a clinical-significance-based classification. In a single-center retrospective study at a public hospital, a review of the last 5,100 coronary angiographies was performed in order to select patients with CAAs. The CAAs were classified into 4 categories on the basis of a literature review according to angiographic appearance and clinical significance: benign (class I); relevant\u2014associated with fixed myocardial ischemia (class II); severe\u2014related to sudden death (class III); and critical\u2014associated with superimposed coronary artery disease (CAD) (class IV). Clinical and instrumental records of the selected patients were reviewed as well as the occurrence of cardiovascular events from the date of diagnosis to July 2002. Sixty-two patients (1.2%, women\/men 20\/42, mean age 65.3 \u00b110.6 years) had CAA on coronary angiography. From the above-described classification, 40 patients were categorized in class I (64.5%), 9 in class II (14.5%), 7 in class III (11.3%), and 6 in class IV (9.7%). During the follow-up (mean duration 60.4 \u00b112.3 months) most cardiovascular events and death occurred in class III and IV patients (71.3% and 100% respectively). A high correlation was found between significance level and percentage of patients with cardiovascular events ( r =0.99). Actuarial survival at 5 years was 82.9%. CAAs can be practically classified on the basis of clinical presentation and significance. This clinical classification may be useful in managing patients with CAA and personalizing their follow-up and therapeutic options according to their class and case histories.<\/jats:p>","DOI":"10.1177\/000331970505600104","type":"journal-article","created":{"date-parts":[[2006,3,31]],"date-time":"2006-03-31T16:26:23Z","timestamp":1143822383000},"page":"25-34","source":"Crossref","is-referenced-by-count":37,"title":["Validation of a Clinical-Significance-Based Classification of Coronary Artery Anomalies"],"prefix":"10.1177","volume":"56","author":[{"given":"Gianluca","family":"Rigatelli","sequence":"first","affiliation":[{"name":"EndoCardioVascular Therapy Research, Legnago, Verona, Italy,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Docali","sequence":"additional","affiliation":[{"name":"Department of Special Medicine, Division of Cardiology, Legnago General Hospital, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Special Medicine, Division of Cardiology, Legnago General Hospital, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attilio","family":"Bandello","sequence":"additional","affiliation":[{"name":"Department of Special Medicine, Division of Cardiology, Legnago General Hospital, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Rigatelli","sequence":"additional","affiliation":[{"name":"Department of Special Medicine, Division of Cardiology, Legnago General Hospital, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2005,1,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(83)90363-0"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1148\/130.1.39"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/0033-0620(83)90019-1"},{"key":"atypb4","first-page":"404","volume-title":"Heart Disease. A Text Book of Cardiovascular Medicine","author":"Popma JJ","year":"2001"},{"key":"atypb5","first-page":"125","volume-title":"Congenital Heart Disease in the Adult","author":"Gerson WM","year":"2001"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.1810210110"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000016175.49835.57"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960161005"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0304(199711)42:3<270::AID-CCD8>3.0.CO;2-9"},{"key":"atypb10","first-page":"636","volume":"8","author":"Gol MK","year":"2002","journal-title":"Med Sci Monit"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(89)90588-3"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5273(92)90148-V"},{"key":"atypb13","first-page":"27","volume-title":"Coronary Artery Anomalies: A Comprehensive Approach","author":"Angelini P","year":"1999"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(00)00243-6"},{"key":"atypb15","first-page":"271","volume":"54","author":"Harikrishnan S","year":"2002","journal-title":"Indian Heart J"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)01315-1"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1007\/s003300000506"},{"key":"atypb18","first-page":"68","volume":"2","author":"Rigatelli GL","year":"2001","journal-title":"Ital Heart J"},{"key":"atypb19","first-page":"165","volume":"49","author":"Rigatelli GL","year":"2001","journal-title":"Minerva Cardioangiol"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a059784"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(88)90424-X"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)33718-3"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200209193471221"},{"key":"atypb24","first-page":"669","volume":"2","author":"Balanescu S","year":"2001","journal-title":"Ital Heart J"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(02)03633-0"},{"key":"atypb26","first-page":"587","volume":"86","author":"Serraf A","year":"1993","journal-title":"Arch Mal Coeur Vaiss"},{"key":"atypb27","first-page":"769","volume":"1","author":"Pedon L","year":"2000","journal-title":"Ital Heart J"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1097\/00045415-200111000-00005"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.3109\/15513819409024261"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90019-J"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(84)80253-3"},{"key":"atypb32","doi-asserted-by":"publisher","DOI":"10.1016\/S0379-0738(98)00113-3"},{"key":"atypb33","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(80)90319-1"},{"key":"atypb34","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006161821388"},{"key":"atypb35","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S0003-4975(99)00405-1","volume":"68","author":"Maluf MA","year":"1999","journal-title":"Ann Thorac Surg"},{"key":"atypb36","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(98)00716-4"},{"key":"atypb37","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.128.2.257"},{"key":"atypb38","first-page":"153","volume":"50","author":"Rigatelli GL","year":"2002","journal-title":"Minerva Cardioangiol"},{"key":"atypb39","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.10219"},{"key":"atypb40","doi-asserted-by":"publisher","DOI":"10.1177\/000331970105200803"},{"key":"atypb41","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2002.123118"}],"container-title":["Angiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000331970505600104","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000331970505600104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:13:26Z","timestamp":1777371206000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000331970505600104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["10.1177\/000331970505600104"],"URL":"https:\/\/doi.org\/10.1177\/000331970505600104","relation":{},"ISSN":["0003-3197","1940-1574"],"issn-type":[{"value":"0003-3197","type":"print"},{"value":"1940-1574","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,1]]}}}