{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:50:56Z","timestamp":1777398656078,"version":"3.51.4"},"reference-count":6,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angiology"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:p>Endothelin-1 (ET-1) is known to be a principal factor in the pathogenesis of primary pulmonary hypertension (PPH). Recently intravenous administration of epoprosterol improved the survival rate in PPH. However, the effect of epoprosterol on ET-1 remains to be investigated. Therefore, we studied a patient with PPH who was treated with a low dose of epoprosterol and examined the serum concentration of ET-1 during the treatment. Epoprosterol greatly decreased the serum concentration of ET-1 in parallel with improvement of the clinical course, suggesting that ET-1 level may be a marker for treatment of PPH.<\/jats:p>","DOI":"10.1177\/000331970505600519","type":"journal-article","created":{"date-parts":[[2006,3,31]],"date-time":"2006-03-31T16:26:23Z","timestamp":1143822383000},"page":"641-645","source":"Crossref","is-referenced-by-count":1,"title":["Continuous Intravenous Administration of a Low Dose of Epoprostenol Greatly Decreased Serum Concentrations of Endothelin-1 in Primary Pulmonary Hypertension"],"prefix":"10.1177","volume":"56","author":[{"given":"Yoshihiko","family":"Kakinuma","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Control, Kochi Medical School, Kochi, and Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Honma","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Control, Kochi Medical School, Kochi, and Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Morimoto","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Control, Kochi Medical School, Kochi, and Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidekazu","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Control, Kochi Medical School, Kochi, and Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Control, Kochi Medical School, Kochi, and Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Ishimitsu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Control, Kochi Medical School, Kochi, and Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iwao","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Control, Kochi Medical School, Kochi, and Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2005,9,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199602013340504"},{"key":"atypb2","first-page":"1195","volume":"26","author":"Farber HW","year":"1999","journal-title":"J Rheumatol"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.61.1.391"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.21.2169"},{"key":"atypb5","first-page":"I-586","volume":"100","author":"Ueno M","year":"1999","journal-title":"Circulation"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.85.5.394"}],"container-title":["Angiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000331970505600519","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000331970505600519","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:13:41Z","timestamp":1777371221000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000331970505600519"}},"subtitle":["A Case Report"],"short-title":[],"issued":{"date-parts":[[2005,9]]},"references-count":6,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["10.1177\/000331970505600519"],"URL":"https:\/\/doi.org\/10.1177\/000331970505600519","relation":{},"ISSN":["0003-3197","1940-1574"],"issn-type":[{"value":"0003-3197","type":"print"},{"value":"1940-1574","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,9]]}}}