{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:53:20Z","timestamp":1777398800560,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angiology"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:p>A 46-year-old man was admitted for further evaluation of exertional chest discomfort. One family member had experienced sudden death, and 2 others had died of heart failure, including 1 known to have had Fabry\u2019s disease. The patient was also diagnosed with Fabry\u2019s disease, based on reduced leukocyte a-galactosidase A activity, 2.0 nmol\/mg protein\/hour, as well as endomyocardial biopsy findings of marked sarcoplasmic vacuolization of cardiac muscle cells by light microscopy and lamellated \u201czebra bodies\u201d in the cytoplasm shown by electron microscopy. Echocardiography disclosed marked left ventricular hypertrophy and systolic anterior motion of the mitral leaflets. On cardiac catheterization, a left ventricular peak systolic outflow gradient of 50 mm Hg was noted; this decreased to 10 mm Hg following intravenous administration of 100 mg of cibenzoline. It is imperative to recognize the existence of cases with Fabry\u2019s disease associated with left ventricular outflow obstruction.<\/jats:p>","DOI":"10.1177\/000331970605700217","type":"journal-article","created":{"date-parts":[[2007,6,21]],"date-time":"2007-06-21T21:04:37Z","timestamp":1182459877000},"page":"241-245","source":"Crossref","is-referenced-by-count":4,"title":["Relief of Left Ventricular Outflow Obstruction by Cibenzoline in a Patient With Fabry\u2019s Disease"],"prefix":"10.1177","volume":"57","author":[{"given":"Shin-ichiro","family":"Morimoto","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Japan,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Sugiura","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatsugu","family":"Iwase","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natsuko","family":"Kubo","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Hiramitsu","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihisa","family":"Uemura","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatsugu","family":"Ohtsuki","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Kato","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuchika","family":"Kato","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Hishida","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2006,3,1]]},"reference":[{"key":"atypb1","first-page":"2276","volume-title":"Harrison\u2019s Principles of Internal Medicine","author":"Grabowski GA","year":"2001","edition":"15"},{"key":"atypb2","first-page":"2741","volume-title":"Fabry Disease. 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