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The objective is to study the effects of isosorbide dinitrate-spray in patients with chronic venous ulcers. Forty-five patients of both sexes with chronic venous ulcers were randomized to receive isosorbide dinitrate or placebo sprays daily for 3 months. The ulcers were measured and clinical characteristics were taken every 15 days during the treatment. Patients treated with isosorbide dinitrate showed an improvement of the ulcerated area (71.29%) compared with patients treated with placebo (54.35%). The histopathological study indicated an increment in the number of hypertrophic and hyperplasic capillaries. Macroscopically, the isosorbide dinitrate-treatment showed the best results, but it was only during the first 6 weeks of treatment. Patients with chronic venous ulcer receiving isosorbide dinitrate spray showed improvement.<\/jats:p>","DOI":"10.1177\/0003319707303700","type":"journal-article","created":{"date-parts":[[2008,3,3]],"date-time":"2008-03-03T23:13:03Z","timestamp":1204585983000},"page":"64-71","source":"Crossref","is-referenced-by-count":9,"title":["Isosorbide Dinitrate Spray as Therapeutic Strategy for Treatment of Chronic Venous Ulcers"],"prefix":"10.1177","volume":"59","author":[{"given":"Rene","family":"S\u00e1nchez-V\u00e1zquez","sequence":"first","affiliation":[{"name":"Unidad de Investigaci\u00f3n Cardiovascular, CUCS, Universitdad de Guadalajara"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Brise\u00f1o-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Cardiovascular, CUCS, Universitdad de Guadalajara"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernesto 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