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Using optical aggregometer, maximal platelet aggregation values were measured with induction of adenosine diphosphate, collagen, and adrenaline 30 \u00b1 5 days after coronary stent implantation in 134 patients. Markers of platelet activation were also analyzed with fluorescent immunoassay in 57 patients. After 10 months of follow-up, 33 patients reached the composite endpoint of cardiovascular death, myocardial infarction, and revascularisation. Adenosine diphosphate-induced maximal aggregation values were in significant relationship with the development of major adverse cardiac events ( P &lt; .01). Level of soluble P-selectin proved to be an independent risk factor of adverse outcome ( P &lt; .05). As efficacy of thienopyridine therapy showed significant relation with clinical outcome, the authors conclude that interindividual variability in response to adenosine diphosphate-receptor antagonists may be of substantial clinical importance.<\/jats:p>","DOI":"10.1177\/0003319707304572","type":"journal-article","created":{"date-parts":[[2008,4,3]],"date-time":"2008-04-03T20:25:56Z","timestamp":1207254356000},"page":"172-178","source":"Crossref","is-referenced-by-count":9,"title":["Thienopyridine Therapy Influences Late Outcome After Coronary Stent Implantation"],"prefix":"10.1177","volume":"59","author":[{"given":"D\u00e1niel","family":"Aradi","sequence":"first","affiliation":[{"name":"Department of Interventional Cardiology, Heart Institute, University of P\u00e9cs"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attila","family":"K\u00f3nyi","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Heart Institute, University of P\u00e9cs"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3","family":"P\u00e1link\u00e1s","sequence":"additional","affiliation":[{"name":"Institute of Immunbiology and Immuntechnology University of P\u00e9cs, P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T\u00edmea","family":"Berki","sequence":"additional","affiliation":[{"name":"Institute of Immunbiology and Immuntechnology University of P\u00e9cs, P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T\u00fcnde","family":"Pint\u00e9r","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Heart Institute, University of P\u00e9cs"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tam\u00e1s","family":"Tahin","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Heart Institute, University of P\u00e9cs"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iv\u00e1n","family":"Horv\u00e1th","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Heart Institute, University of P\u00e9cs"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lajos","family":"Papp","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Heart Institute, University of P\u00e9cs"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e1s","family":"Kom\u00f3csi","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Heart Institute, University of P\u00e9cs,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,4,2]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.20.2126"},{"key":"atypb2","first-page":"1597","volume":"98","author":"Bertrand ME","year":"1998","journal-title":"The full anticoagulation versus aspirin and ticlopidine (FANTASTIC) study. 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