{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:05:52Z","timestamp":1777399552795,"version":"3.51.4"},"reference-count":6,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2009,4,26]],"date-time":"2009-04-26T00:00:00Z","timestamp":1240704000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angiology"],"published-print":{"date-parts":[[2009,6]]},"abstract":"\n Introduction<\/jats:title>\n Patients on intravenous heparin require regular activated partial thromboplastin time monitoring. Laboratory-based activated partial thromboplastin time assays necessitate a delay between blood sampling and dose adjustment. Point-of-care testing could permit immediate dose adjustments, potentially enabling tighter control of anticoagulation.<\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n To assess equivalence of activated partial thromboplastin time measured by conventional laboratory assay and by a novel proprietary point-of-care testing system (Hemochron Response, ITC, Thoratec Corporation, Edison, NJ) among surgical ward patients on intravenous heparin.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A total of 39 blood samples from patients on intravenous heparin were tested with both laboratory and point-of-care assays. Assay equivalence was assessed by Bland-Altman analysis.<\/jats:p>\n <\/jats:sec>\n \n Results.<\/jats:title>\n Point-of-care measurements exceeded laboratory activated partial thromboplastin time by a mean of 15 seconds (standard deviation 19). In 19 cases (49%), the point-of-care measurement would have resulted in different heparin dosing from the laboratory activated partial thromboplastin time.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The Hemochron Response system is not sufficiently accurate for routine ward use compared with laboratory activated partial thromboplastin time assays.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/0003319709332958","type":"journal-article","created":{"date-parts":[[2009,4,27]],"date-time":"2009-04-27T20:13:33Z","timestamp":1240863213000},"page":"358-361","source":"Crossref","is-referenced-by-count":9,"title":["Evaluation of Point-of-care Activated Partial Thromboplastin Time Testing by Comparison to Laboratory-based Assay for Control of Intravenous Heparin"],"prefix":"10.1177","volume":"60","author":[{"given":"Alexander D.","family":"Douglas","sequence":"first","affiliation":[{"name":"Departments of Vascular Surgery, Haematoiogy, and Intensive Care, Oxford Radcliffe Hospitals NHS Trust, Oxford, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo","family":"Jefferis","sequence":"additional","affiliation":[{"name":"Departments of Vascular Surgery, Haematoiogy, and Intensive Care, Oxford Radcliffe Hospitals NHS Trust, Oxford, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rishi","family":"Sharma","sequence":"additional","affiliation":[{"name":"Departments of Vascular Surgery, Haematoiogy, and Intensive Care, Oxford Radcliffe Hospitals NHS Trust, Oxford, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Parker","sequence":"additional","affiliation":[{"name":"Departments of Vascular Surgery, Haematoiogy, and Intensive Care, Oxford Radcliffe Hospitals NHS Trust, Oxford, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashok","family":"Handa","sequence":"additional","affiliation":[{"name":"Departments of Vascular Surgery, Haematoiogy, and Intensive Care, Oxford Radcliffe Hospitals NHS Trust, Oxford, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Chantler","sequence":"additional","affiliation":[{"name":"Departments of Vascular Surgery, Haematoiogy, and Intensive Care, Oxford Radcliffe Hospitals NHS Trust, Oxford, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,4,26]]},"reference":[{"key":"bibr1-0003319709332958","doi-asserted-by":"publisher","DOI":"10.1160\/TH06-05-0290"},{"key":"bibr2-0003319709332958","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1051\/ject\/2002344271","volume":"34","author":"Jaryno S.","year":"2002","journal-title":"J Extra Corpor Technol."},{"key":"bibr3-0003319709332958","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021298103264"},{"key":"bibr4-0003319709332958","first-page":"744","volume":"36","author":"Weightman W.","year":"2008","journal-title":"Anaesth Intensive Care."},{"key":"bibr5-0003319709332958","unstructured":"Available at: http:\/\/itcmed.com\/documents\/response_en.pd.; accessed date: 30 Nov 2008."},{"key":"bibr6-0003319709332958","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90837-8"}],"container-title":["Angiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0003319709332958","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0003319709332958","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:15:21Z","timestamp":1777371321000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0003319709332958"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4,26]]},"references-count":6,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["10.1177\/0003319709332958"],"URL":"https:\/\/doi.org\/10.1177\/0003319709332958","relation":{},"ISSN":["0003-3197","1940-1574"],"issn-type":[{"value":"0003-3197","type":"print"},{"value":"1940-1574","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,26]]}}}