{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:34:24Z","timestamp":1791516864758,"version":"4.3.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2010,5,24]],"date-time":"2010-05-24T00:00:00Z","timestamp":1274659200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angiology"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:p>Portopulmonary hypertension (PPHTN) is a rare complication in patients with portal hypertension. A role of endothelin 1 (ET-1) and other cytokines was demonstrated in primary pulmonary hypertension but not in PPHTN. We evaluated the possible role of ET-1, interleukin 6 (IL-6), interleukin 1\u03b2 (IL-1\u03b2), and tumor necrosis factor alpha (TNF-\u03b1) in the pathogenesis of PPHTN. Plasmatic concentrations of ET-1, IL-6, IL-1\u03b2, and TNF-\u03b1 were measured in patients with pulmonary systolic arterial pressure (PAPs) &gt;30 mm Hg and in patients with cirrhosis. In all, Six out of 11 patients with PAPs &gt;30 mm Hg had PPHTN on right heart catheterization. The remaining 10 patients had an hyperdynamic circulation (HC). In PPHTN patients, ET-1 and IL-6 were significantly higher compared with HC and patients with cirrhosis. Endothelin 1 and IL-6 could be implicated in the pathogenesis of PPHTN. On the basis of these results, ET-1 receptor antagonists or anti-IL-6 could have a rationale in the treatment of PPHTN.<\/jats:p>","DOI":"10.1177\/0003319710369101","type":"journal-article","created":{"date-parts":[[2010,5,24]],"date-time":"2010-05-24T23:26:55Z","timestamp":1274743615000},"page":"802-806","source":"Crossref","is-referenced-by-count":58,"title":["Plasma Cytokines and Portopulmonary Hypertension in Patients With Cirrhosis Waiting for Orthotopic Liver Transplantation"],"prefix":"10.1177","volume":"61","author":[{"given":"Adriano M.","family":"Pellicelli","sequence":"first","affiliation":[{"name":"Liver Unit, Azienda Ospedaliera San Camillo, Forlanini, Rome, Italy,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Barbaro","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Department of Medical Pathophysiology, University La Sapienza, Rome, 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