{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:20:47Z","timestamp":1791080447382,"version":"4.1.0"},"reference-count":48,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2012,7,23]],"date-time":"2012-07-23T00:00:00Z","timestamp":1343001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Angiology"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:p>\n                    We examined the association between the \u220a4 allele of the apolipoprotein E gene and severity of peripheral neuropathy in 234 patients with type 2 diabetes mellitus (T2DM). Based on the Neuropathy Disability Score (NDS), patients were divided into group A (NDS \u22646: mild or no neuropathy) and group B (NDS &gt;6: severe neuropathy). In each group, patients were further divided into \u220a4 carriers and non-\u220a4 carriers. In multivariate analysis, a more than 5-fold increased risk of severe neuropathy was associated with \u220a4 carrier status (adjusted odds ratio [aOR]: 5.26, 95% confidence interval [CI]: 2.24-12.31, P = .0001). The other significant risk factors for severe neuropathy included male gender (aOR: 2.08, 95% CI: 1.05-4.14, P = .036), diabetes duration (aOR: 1.05, 95% CI: 1.00-1.09, P = .039), and hemoglobin A\n                    <jats:sub>1c<\/jats:sub>\n                    (aOR: 1.32, 95% CI: 1.05-1.66, P = .020). In conclusion, the \u220a4 carrier status appears to be associated with severe peripheral neuropathy in T2DM.\n                  <\/jats:p>","DOI":"10.1177\/0003319712453645","type":"journal-article","created":{"date-parts":[[2012,7,23]],"date-time":"2012-07-23T20:59:57Z","timestamp":1343077197000},"page":"451-455","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["The \u03b54 Allele of the APOE Gene Is Associated With More Severe Peripheral Neuropathy in Type 2 Diabetic Patients"],"prefix":"10.1177","volume":"64","author":[{"given":"C.","family":"Monastiriotis","sequence":"first","affiliation":[{"name":"Outpatient Clinic of the Diabetic Foot, Second Department of Internal Medicine, Democritus University of Thrace, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Papanas","sequence":"additional","affiliation":[{"name":"Outpatient Clinic of the Diabetic Foot, Second 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