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The objective of this study is to determine the clinical characteristics and differences between 831 asymptomatic individuals with very high CAC scores (CACS \u22651000) and 497 asymptomatic individuals with CAC scores of 400 to 999. Individuals with CACS \u22651000 were more likely to have hypertension ([HTN]; P = .0004), hypercholesterolemia ( P = .0001), diabetes mellitus ([DM] P = .005), and high body mass index ([BMI]; P = .03) compared with individuals with CACS = 400-999. On multivariable analysis, age ( P &lt; .0001) and BMI ( P = .01) were found to be significant risk factors for the presence of very high CAC. While for males, age ( P &lt; .0001), hypercholesterolemia ( P = .001), DM ( P = .002), and obesity ( P = .003) were independent risk factors; in females only HTN ( P = .04) was independent risk factor.<\/jats:p>","DOI":"10.1177\/0003319712454217","type":"journal-article","created":{"date-parts":[[2012,7,28]],"date-time":"2012-07-28T06:54:13Z","timestamp":1343458453000},"page":"435-439","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Differences in Clinical Profile of Individuals With Severe and Markedly Elevated Coronary Artery Calcification Detected by Electron Beam Computed Tomography"],"prefix":"10.1177","volume":"64","author":[{"given":"G.","family":"Koulaouzidis","sequence":"first","affiliation":[{"name":"Heart Centre and Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden"},{"name":"European Scanning Centre, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Charisopoulou","sequence":"additional","affiliation":[{"name":"Royal Brompton and Harefield NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Maffrett","sequence":"additional","affiliation":[{"name":"European Scanning Centre, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Tighe","sequence":"additional","affiliation":[{"name":"European Scanning Centre, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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