{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:24:26Z","timestamp":1777400666404,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T00:00:00Z","timestamp":1384992000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Angiology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:p>We investigated the relation between diabetic autonomic neuropathy (DAN) and left ventricular (LV) function in 59 patients with type 2 diabetes mellitus (T2DM) free of coronary artery disease (CAD) or hypertension. Diabetic autonomic neuropathy was established by \u22652 abnormal autonomic nervous function tests. Left ventricular systolic and diastolic functions were assessed by resting radionuclide ventriculography. Compared with non-DAN patients (n = 24), patients with DAN (n = 35) had an increased adjusted atrial contribution to ventricular filling (A\/V%, 30.1% \u00b1 8.2% vs 26.5% \u00b1 5.1%; P = .031), suggestive of diastolic dysfunction (DD). There were no differences between the 2 groups in peak filling rate, first 1\/3 filling fraction, ejection fraction, cardiac output, and cardiac index. Patients with diabetic autonomic neuropathy had an increased heart rate (77.8 \u00b1 6.3 vs 69.3 \u00b1 3.3 bpm; P &lt; .0001) and a higher rest LV workload (10 072 \u00b1 1165 vs 8606 \u00b1 1075 bpm mm Hg; P &lt; .0001). Patients with DAN T2DM without CAD or hypertension have DD, increased A\/V index, and a higher LV working load than non-DAN patients.<\/jats:p>","DOI":"10.1177\/0003319713510966","type":"journal-article","created":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T22:36:53Z","timestamp":1385073413000},"page":"877-882","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Left Ventricular Systolic and Diastolic Function in Normotensive Type 2 Diabetic Patients With or Without Autonomic Neuropathy"],"prefix":"10.1177","volume":"65","author":[{"given":"Triantafyllos P.","family":"Didangelos","sequence":"first","affiliation":[{"name":"First Propeudetic Department of Internal Medicine, Diabetes Center, Medical School, Aristotle University of Thessaloniki, \u201cAHEPA\u2019\u2019 Hospital, Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios","family":"Arsos","sequence":"additional","affiliation":[{"name":"Laboratory of Nuclear Medicine, Medical School, Aristotle University of Thessaloniki, Papageorgiou Hospital, Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodoros","family":"Karamitsos","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fotios","family":"Iliadis","sequence":"additional","affiliation":[{"name":"First Propeudetic Department of Internal Medicine, Diabetes Center, Medical School, Aristotle University of Thessaloniki, \u201cAHEPA\u2019\u2019 Hospital, Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athanasios","family":"Papageorgiou","sequence":"additional","affiliation":[{"name":"Second 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