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Half of the obese rats (obese + estradiol, n = 7) were treated with a single dose of estradiol (40 \u03bcg\/kg, intraperitoneally) and 24 hours after treatment all the rats were killed. Estradiol in vivo in obese rats resulted in a significant increase in protein kinase B (Akt) activation ( P &lt; .05) and decrease in heart mass ( P &lt; .05), ratio of the heart mass\/body mass ( P &lt; .05), transverse diameters of cardiomyocytes ( P &lt; .001), concentration of serum high-sensitivity C-reactive protein ( P &lt; .001), and total cholesterol ( P &lt; .01) compared with obese nontreated rats. Our results suggest that estradiol in obese\/IR rats affects the size of cardiomyocytes and its actions lead in vivo to a reduction in obesity-induced cardiac hypertrophy, via Akt.<\/jats:p>","DOI":"10.1177\/0003319713514477","type":"journal-article","created":{"date-parts":[[2013,12,10]],"date-time":"2013-12-10T20:39:10Z","timestamp":1386707950000},"page":"25-35","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":28,"title":["Estradiol In Vivo Induces Changes in Cardiomyocytes Size in Obese Rats"],"prefix":"10.1177","volume":"66","author":[{"given":"Milan","family":"Obradovic","sequence":"first","affiliation":[{"name":"Institute Vinca, University of Belgrade, Laboratory of Radiobiology and Molecular Genetics, Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emina","family":"Sudar","sequence":"additional","affiliation":[{"name":"Institute Vinca, University of Belgrade, Laboratory of Radiobiology and Molecular Genetics, Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonja","family":"Zafirovic","sequence":"additional","affiliation":[{"name":"Institute Vinca, University of Belgrade, Laboratory of Radiobiology and Molecular Genetics, Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julijana","family":"Stanimirovic","sequence":"additional","affiliation":[{"name":"Institute Vinca, University of Belgrade, Laboratory of Radiobiology and Molecular Genetics, Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milica","family":"Labudovic-Borovic","sequence":"additional","affiliation":[{"name":"Institute of Histology and Embryology \u201cAleksandar \u00d0. 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