{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:27:10Z","timestamp":1777400830680,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2014,5,15]],"date-time":"2014-05-15T00:00:00Z","timestamp":1400112000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Angiology"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:p>Contrast-induced nephropathy (CIN) is a common complication in patients with impaired kidney function undergoing coronary angiography\/angioplasty. We evaluated whether elevated homocysteine (known to be associated with free radical generation and oxidative stress) increases the risk of CIN. Patients (n = 876) with creatinine clearance &lt;60 mL\/min undergoing coronary angiography or percutaneous coronary intervention (PCI) were divided into tertiles of homocysteine levels. Contrast-induced nephropathy was defined as \u22650.5 mg\/dL or \u226525% creatinine increase 24 to 48 hours post-PCI. A significant relationship was observed between homocysteine levels and the risk of CIN ( P = .033), confirmed after correction for baseline confounding factors, adjusted odds ratio, OR (95% confidence interval, [CI]) = 1.68 (1.09-2.59), P = .019. This association was also significant applying the new definition of contrast-induced acute kidney injury (11.9% in group 1, 10.4% in group 2, and 22.8% in group 3; P &lt; .001), adjusted OR (95% CI) = 1.96 (1.3-2.95), P = .001. Future studies are needed to confirm our findings and to define the role of homocysteine in CIN.<\/jats:p>","DOI":"10.1177\/0003319714533401","type":"journal-article","created":{"date-parts":[[2014,5,16]],"date-time":"2014-05-16T00:39:20Z","timestamp":1400200760000},"page":"333-338","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Elevated Homocysteine and the Risk of Contrast-Induced Nephropathy"],"prefix":"10.1177","volume":"66","author":[{"given":"Lucia","family":"Barbieri","sequence":"first","affiliation":[{"name":"Division of Cardiology, Azienda Ospedaliera-Universitaria \u201cMaggiore della Carit\u00e0,\u201d Eastern Piedmont University, Novara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Verdoia","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Azienda Ospedaliera-Universitaria \u201cMaggiore della Carit\u00e0,\u201d Eastern 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