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Consecutive patients (n = 162) were randomized into 2 groups based on whether intracoronary tirofiban was administered. After the administration of intracoronary tirofiban, thrombolysis in myocardial infarction (TIMI) flow grade significantly increased ( P &lt; .001) and successful reperfusion was achieved in 26 (32%) patients. In the placebo group, however, after the administration of intracoronary placebo the TIMI flow grade did not change ( P = .070), and successful reperfusion was achieved only in 8 (10%) patients. In-hospital major adverse cardiac events (MACE) were significantly lower in the tirofiban group (36% vs 19%, P = .013). Intracoronary administration of tirofiban significantly improves TIMI flow grade and is associated with a lower in-hospital rate of MACE.<\/jats:p>","DOI":"10.1177\/0003319714545780","type":"journal-article","created":{"date-parts":[[2014,8,5]],"date-time":"2014-08-05T00:55:39Z","timestamp":1407200139000},"page":"560-567","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Acute Effects of Intracoronary Tirofiban on No-Reflow Phenomena in Patients With ST-Segment Elevated Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention"],"prefix":"10.1177","volume":"66","author":[{"given":"Mahmut","family":"Akpek","sequence":"first","affiliation":[{"name":"Department of Cardiology, Kayseri Education and Research Hospital, Kayseri, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omer","family":"Sahin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, 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