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We measured these variables in 24 patients with MVD as well as in 21 with MVD + AF and compared them with 20 healthy controls (HCs). The CECs and PMPs were measured by flow cytometry; sPsel, oxLDL, and CD40 by enzyme-linked immunosorbent assay. Compared with HCs, sPsel and PMPs were equally higher in MVD and MVD + AF; sCD40 and oxLDL were higher in MVD + AF than in HCs and MVD; and CECs were higher in MVD than in the HCs, with further increases in MVD + AF (all P &lt; .001). We conclude that excess platelet activation is present in MVD regardless of AF, and that increased endothelial damage in MVD is greater when compounded by AF.<\/jats:p>","DOI":"10.1177\/0003319714546183","type":"journal-article","created":{"date-parts":[[2014,8,13]],"date-time":"2014-08-13T09:48:58Z","timestamp":1407923338000},"page":"631-637","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Circulating Endothelial Cells and Platelet Microparticles in Mitral Valve Disease With and Without Atrial Fibrillation"],"prefix":"10.1177","volume":"66","author":[{"given":"Naglaa K.","family":"Idriss","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine, Assiut University, Assiut, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew D.","family":"Blann","sequence":"additional","affiliation":[{"name":"Department of Medicine City Hospital, 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