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Randomized trials comparing Biv versus Hep were eligible for inclusion. With imbalanced GPI use, Biv had significantly lower major bleeding (pooled risk ratio [RR], 0.67; 95% confidence interval [CI], 0.54-0.83) without difference in mortality (pooled RR, 0.95; 95% CI, 0.80-1.14). With comparable GPI use, no significant difference was observed in major bleeding (pooled RR, 0.95; 95% CI, 0.82-1.10) and mortality (pooled RR, 1.13; 95% CI, 0.85-1.50). With no GPI use, Biv was associated with numerically higher mortality (pooled RR, 1.17; 95% CI, 0.83-1.65) without significant difference in major bleeding (pooled RR, 0.81; 95% CI, 0.64-1.02). In conclusion, when comparing different anticoagulants during PCI, the effect of GPIs should not be underestimated. Heparin as such was found noninferior to Biv.<\/jats:p>","DOI":"10.1177\/0003319715568972","type":"journal-article","created":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T01:26:23Z","timestamp":1422581183000},"page":"845-855","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Heparin is Not Inferior to Bivalirudin in Percutaneous Coronary Intervention\u2014Focusing on the Effect of Glycoprotein IIb\/IIIa Inhibitor Use"],"prefix":"10.1177","volume":"66","author":[{"given":"Fang-Yang","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bao-Tao","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 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