{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:23:51Z","timestamp":1777400631391,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T00:00:00Z","timestamp":1433376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Angiology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:p>Arterial stiffness is thought to be a precursor to atherosclerosis. Conventional arterial stiffness parameters as potential biomarkers of radiation-induced damage were investigated. Patients with head and neck cancer treated with radiotherapy \u22652 years previously to one side of the neck were included. The unirradiated side was the internal control. Beta stiffness index (B) and elastic modulus ( Ep) were used to assess arterial stiffness and were measured in proximal, mid, and distal common carotid artery (CCA) and compared with the corresponding unirradiated segments. Fifty patients (68% male; median age 58 years; interquartile range 50-62) were included. Mean \u00b1 standard deviation maximum doses to irradiated and unirradiated arteries were 53 \u00b1 13 and 1.9 \u00b1 3.7 Gy, respectively. Differences in B were not significant. Significant differences in Ep were demonstrated\u2014proximal CCA: 1301 \u00b1 1223 versus 801 \u00b1 492 ( P &lt; .0001), mid CCA: 1064 \u00b1 818 versus 935.5 \u00b1 793 ( P &lt; .0001), and distal CCA: 1267 \u00b1 1084 versus 775.3 \u00b1 551.9 ( P &lt; .0001). Surgery had no impact on arterial stiffness. Arterial stiffness is increased in irradiated arteries, in keeping with radiation-induced damage. Prospective data may show an association between arterial stiffness and atherosclerosis in this setting.<\/jats:p>","DOI":"10.1177\/0003319715589520","type":"journal-article","created":{"date-parts":[[2015,6,5]],"date-time":"2015-06-05T00:01:30Z","timestamp":1433462490000},"page":"266-271","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Arterial Stiffness as a Biomarker of Radiation-Induced Carotid Atherosclerosis"],"prefix":"10.1177","volume":"67","author":[{"given":"Dorothy M.","family":"Gujral","sequence":"first","affiliation":[{"name":"Head and Neck Unit, The Royal Marsden Hospital, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benoy N.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Echocardiography, Royal Brompton Hospital, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Navtej 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