{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T08:22:40Z","timestamp":1792570960372,"version":"4.5.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2016,7,11]],"date-time":"2016-07-11T00:00:00Z","timestamp":1468195200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Angiology"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>To assess the nationwide contemporary burden of cardiovascular risk factors, comorbidities, and in-hospital mortality in patients with lower limb amputation (LLA) due to peripheral arterial disease and critical limb ischemia (CLI) in Germany.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>German nationwide data for 2005 and 2009 were analyzed regarding in-hospital rates of major and minor ischemic LLA, risk factors, comorbidities, surgical and endovascular revascularizations, and in-hospital mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In 2005, a total of 22 479 major (7.8%) and 28 262 minor (9.8%) LLAs were performed with a relative decrease of \u221221.8% in major LLA, yet with a relative increase of +2% in minor LLA rate in 2009. The overall revascularization rate before amputation was 46% in 2005 and 57% in 2009. In-hospital mortality for non-CLI, minor, and major amputees was 3.3%, 4.6%, and 19.8%, respectively ( P &lt; .001 for major vs minor LLA and non-CLI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The total number of ischemic LLA and amputation-related in-hospital mortality remains high in Germany in the 21st century. The poor outcome of patients with CLI might in part be due to underuse of revascularizations prior to amputation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0003319715626849","type":"journal-article","created":{"date-parts":[[2016,1,14]],"date-time":"2016-01-14T00:59:30Z","timestamp":1452733170000},"page":"860-869","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":41,"title":["Low Rates of Revascularization and High In-Hospital Mortality in Patients With Ischemic Lower Limb Amputation"],"prefix":"10.1177","volume":"67","author":[{"given":"Nasser M.","family":"Malyar","sequence":"first","affiliation":[{"name":"Division of Vascular Medicine, Department of Cardiovascular Medicine, University Hospital of Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Freisinger","sequence":"additional","affiliation":[{"name":"Division of Vascular Medicine, Department of Cardiovascular Medicine, University Hospital of Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Meyborg","sequence":"additional","affiliation":[{"name":"Division of Vascular Medicine, Department of Cardiovascular Medicine, University Hospital of Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"L\u00fcders","sequence":"additional","affiliation":[{"name":"Division of Vascular Medicine, Department of Cardiovascular Medicine, University Hospital of Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"F\u00fcrstenberg","sequence":"additional","affiliation":[{"name":"IGES Institut GmbH, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Knut","family":"Kr\u00f6ger","sequence":"additional","affiliation":[{"name":"Department of Angiology, Helios Klinikum Krefeld, Krefeld, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Torsello","sequence":"additional","affiliation":[{"name":"Center for Vascular and Endovascular Surgery, University Hospital of Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Reinecke","sequence":"additional","affiliation":[{"name":"Division of Vascular Medicine, Department of Cardiovascular Medicine, University Hospital of Muenster, 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