{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:16:36Z","timestamp":1789557396122,"version":"build-2803163510"},"reference-count":24,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2017,3,23]],"date-time":"2017-03-23T00:00:00Z","timestamp":1490227200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Angiology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:p>We describe the cardiovascular risk factors, clinical presentation, and prognosis in a comparative study of patients with peripheral artery disease (PAD) from the Cohorte des Patients ART\u00e9riopathes (COPART) cohort, which includes patients hospitalized for PAD in France. Among the 2514 patients included in the cohort, 189 had PAD before or at the age of 50 years and 2325 had it after. Young patients with PAD had diabetes less frequently (34% vs 46%, P &lt; .001), were more frequent active smokers (58% vs 23%, P &lt; 0.001), had lower high-density lipoprotein cholesterol (HDL-C; 41 \u00b1 14 vs 44 \u00b1 15 mg\/dL, P = .026), and had a less frequent family and personal history of coronary heart disease. In a subset of 59 patients whose lipoprotein (a) (Lp(a)) was measured, the Lp(a) levels were higher in the young patients than in the older ones (89.7 mg\/dL [9.7-151.3] vs 19.9 mg\/dL [3.0-207.9], P = .004). Survival and amputation-free survival was 2.2 times higher (1.5-3.2, P &lt; .001) in the young after 1 year. The onset of PAD before 50 years was associated with active smoking, low HDL-C, high Lp(a), and lower mortality.<\/jats:p>","DOI":"10.1177\/0003319717699501","type":"journal-article","created":{"date-parts":[[2017,3,23]],"date-time":"2017-03-23T03:35:03Z","timestamp":1490240103000},"page":"893-898","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Peripheral Atheromatous Arterial Disease in the Young: Risk Factors, Clinical Features, and Prognosis From the COPART Cohort"],"prefix":"10.1177","volume":"68","author":[{"given":"Alexandre","family":"Maillet","sequence":"first","affiliation":[{"name":"M\u00e9decine vasculaire, H\u00f4pital St Andre, Bordeaux, France"},{"name":"Bordeaux University, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ileana","family":"Desormais","sequence":"additional","affiliation":[{"name":"M\u00e9decine vasculaire, H\u00f4pital Dupuytren, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra Bura","family":"Rivi\u00e8re","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Vasculaire, CHU Toulouse, Toulouse, France"},{"name":"StromaLab UMR 5273\/INSERM U1031, Toulouse, France"},{"name":"Universit\u00e9 de Toulouse III, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Aboyans","sequence":"additional","affiliation":[{"name":"Service de Cardiologie, H\u00f4pital Universitaire Dupuytren, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Lacroix","sequence":"additional","affiliation":[{"name":"M\u00e9decine vasculaire, H\u00f4pital Dupuytren, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan","family":"Mirault","sequence":"additional","affiliation":[{"name":"Department of Vascular Medicine, H\u00f4pital Europ\u00e9en Georges-Pompidou, Assistance Publique H\u00f4pitaux de Paris, APHP, Paris Descartes University, Sorbonne Paris Cite, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Messas","sequence":"additional","affiliation":[{"name":"Department of Vascular Medicine, H\u00f4pital Europ\u00e9en Georges-Pompidou, Assistance Publique H\u00f4pitaux de Paris, APHP, Paris Descartes University, Sorbonne Paris Cite, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Bataille","sequence":"additional","affiliation":[{"name":"ADIMEP, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00ebl","family":"Constans","sequence":"additional","affiliation":[{"name":"M\u00e9decine vasculaire, H\u00f4pital St Andre, Bordeaux, France"},{"name":"Bordeaux University, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine","family":"Boulon","sequence":"additional","affiliation":[{"name":"M\u00e9decine vasculaire, H\u00f4pital St Andre, Bordeaux, France"},{"name":"Bordeaux University, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,3,23]]},"reference":[{"key":"bibr1-0003319717699501","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.71.3.510"},{"key":"bibr2-0003319717699501","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.11.1317"},{"issue":"2","key":"bibr3-0003319717699501","first-page":"69","volume":"27","author":"Sauvanier M","year":"2002","journal-title":"J Mal 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