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Although it is a well-known entity and new technological and therapeutic advances have been made, this condition remains poorly addressed, with significantly heterogeneous management, especially in nonexperienced centers. This review, from a third-level dedicated inpatient and outpatient cardioangiology structure, aims to provide an updated summary on the topic of CLI of its complexity, encompassing epidemiological, social, economical and, in particular, diagnostic\/imaging issues, together with potential therapeutic strategies (medical, endovascular, and surgical), including the evaluation of cardiovascular risk factors, the diagnosis, and treatment together with prognostic stratification.<\/jats:p>","DOI":"10.1177\/0003319717739387","type":"journal-article","created":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T22:59:26Z","timestamp":1511305166000},"page":"465-474","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Critical Limb Ischemia: A Practical Up-To-Date Review"],"prefix":"10.1177","volume":"69","author":[{"given":"Iacopo","family":"Fabiani","sequence":"first","affiliation":[{"name":"Cardioangiology 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