{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:17:26Z","timestamp":1792019846514,"version":"4.4.0"},"reference-count":45,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2018,5,10]],"date-time":"2018-05-10T00:00:00Z","timestamp":1525910400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Angiology"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:p>A systemic inflammatory reaction is a common feature of both sarcoidosis and atherosclerosis. Endothelial-cell specific molecule 1 (endocan) is a marker of vascular pathology which also shows a correlation with inflammation, endothelial dysfunction, and atherosclerosis. The objective of this study was to evaluate the vascular involvement in sarcoidosis using serum endocan levels and brachial artery flow\u2013mediated dilation (FMD), a marker of endothelial dysfunction. We included 53 patients with sarcoidosis without conventional cardiovascular risk factors and 40 healthy controls. Endothelial function was assessed using FMD. Endocan concentrations were measured using a commercially available enzyme-linked immunoassay. Patients with sarcoidosis had significantly higher endocan levels (306 [68] ng\/mL vs 269 [73] ng\/mL; P = .039) and lower FMD (2.7% [2.3%-3.2%] vs 8% [5%-13%]; P &lt; .001) compared with the healthy group. A negative correlation was found between endocan levels and FMD in the sarcoidosis group ( r = \u2212.325, P &lt; .007). We conclude that sarcoidosis is associated with high levels of endocan and lower FMD values, which may indicate endothelial dysfunction and an early stage of atherosclerosis.<\/jats:p>","DOI":"10.1177\/0003319718775283","type":"journal-article","created":{"date-parts":[[2018,5,11]],"date-time":"2018-05-11T01:25:16Z","timestamp":1526001916000},"page":"878-883","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Endocan Levels and Endothelial Dysfunction in Patients With Sarcoidosis"],"prefix":"10.1177","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8380-3065","authenticated-orcid":false,"given":"Gonul","family":"Aciksari","sequence":"first","affiliation":[{"name":"Department of Cardiology, Istanbul Medeniyet University Goztepe Training and Research Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Kavas","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases, University of Health Sciences, S\u00fcreyyapasa Chest Diseases and Thoracic Surgery Training and Research Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adem","family":"Atici","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Mus State Hospital, Mus, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seref","family":"Kul","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Istanbul Medeniyet University Goztepe Training and Research Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayriye","family":"Erman","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Istanbul Medeniyet University Goztepe Training and Research Hospital, Istanbul, 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