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However, the effectiveness of alprostadil in preventing CIN remains controversial. Thirty-six articles with a total of 5495 patients were included in this study. Both groups (experimental group and control group) received standard hydration therapy. In the experimental group, patients received different doses of alprostadil. Serum creatinine (SCr), blood urea nitrogen (BUN), estimated glomerular filtration rate (eGFR), cystatin C, creatinine clearance rate (CCr), and \u03b22-microglobulin (\u03b22-MG) were measured at 24, 48, and 72 hours after contrast media injection. The incidence of CIN in the experimental group was significantly lower than that in the control group (6.56% vs 16.74%). The level of SCr, cystatin C, BUN, and \u03b22-MG in the experimental group was lower than those in the control group; CCr and eGFR in the experimental group were higher than those in the control group. This study demonstrated that alprostadil may reduce the incidence of CIN in patients undergoing coronary angiogram and\/or percutaneous coronary intervention.<\/jats:p>","DOI":"10.1177\/0003319719825597","type":"journal-article","created":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T17:58:16Z","timestamp":1548266296000},"page":"594-612","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Effect of Alprostadil on the Prevention of Contrast-Induced Nephropathy: A Meta-Analysis of 36 Randomized Controlled Trials"],"prefix":"10.1177","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8288-174X","authenticated-orcid":false,"given":"Jian","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Guangxi Cardiovascular Institute, Nanning, Guangxi, 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