{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:26:50Z","timestamp":1787318810733,"version":"build-2736575974"},"reference-count":49,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T00:00:00Z","timestamp":1603324800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Angiology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:p>\n                    Carotid plaque inflammation assessed by 2-deoxy-2-[\n                    <jats:sup>18<\/jats:sup>\n                    F]fluoro-D-glucose (\n                    <jats:sup>18<\/jats:sup>\n                    F-FDG) positron emission tomography\/computed tomography (PET\/CT) and lipoprotein-associated phospholipase A2 (Lp-PLA\n                    <jats:sub>2<\/jats:sub>\n                    ) levels are higher in symptomatic patients. The aim of this study was to assess correlations between\n                    <jats:sup>18<\/jats:sup>\n                    F-FDG uptake on PET scan of carotid artery plaques, plasma levels of Lp-PLA\n                    <jats:sub>2<\/jats:sub>\n                    , and cerebrovascular symptoms. The study included 45 consecutive patients (22 symptomatic, 23 asymptomatic) with &gt;70% carotid stenosis. Patients were examined by hybrid PET\/CT, and maximum standardized uptake values (SUV\n                    <jats:sub>max<\/jats:sub>\n                    ) were recorded. Blood samples were obtained, and plasma was stored at \u221280 \u00b0C for subsequent Lp-PLA\n                    <jats:sub>2<\/jats:sub>\n                    analysis. Symptomatic and asymptomatic patients showed no significant difference in classical cardiovascular risk factors. Asymptomatic carotid stenosis patients more frequently had a history of coronary artery disease ( P = .025) and peripheral artery disease ( P = .012). The symptomatic group had higher\n                    <jats:sup>18<\/jats:sup>\n                    F-FDG uptake in carotid plaques ( P &lt; .001), higher plasma Lp-PLA\n                    <jats:sub>2<\/jats:sub>\n                    ( P &lt; .01), and higher high-sensitive C-reactive protein ( P = .022). 2-Deoxy-2-[\n                    <jats:sup>18<\/jats:sup>\n                    F]fluoro-D-glucose uptake on PET\/CT and plasma Lp-PLA\n                    <jats:sub>2<\/jats:sub>\n                    show a statistically significant association with the symptomatic status of carotid plaques.\n                  <\/jats:p>","DOI":"10.1177\/0003319720965419","type":"journal-article","created":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T05:08:36Z","timestamp":1603343316000},"page":"260-267","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Carotid Plaque Inflammation Assessed by\n                    <sup>18<\/sup>\n                    F-FDG PET\/CT and Lp-PLA\n                    <sub>2<\/sub>\n                    Is Higher in Symptomatic Patients"],"prefix":"10.1177","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2480-1596","authenticated-orcid":false,"given":"Alicia","family":"Bueno","sequence":"first","affiliation":[{"name":"Angiology and Vascular Surgery Department, Hospital Universitario de Getafe, Madrid, Spain"},{"name":"Getafe Health Research Institute, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Ramon","family":"March","sequence":"additional","affiliation":[{"name":"Angiology and Vascular Surgery Department, Hospital Universitario de Getafe, Madrid, Spain"},{"name":"Getafe Health Research Institute, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Garcia","sequence":"additional","affiliation":[{"name":"Getafe Health Research Institute, Madrid, Spain"},{"name":"Nuclear 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