{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T19:53:00Z","timestamp":1786305180721,"version":"build-2736575974"},"reference-count":23,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T00:00:00Z","timestamp":1607904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Zhongshan Public Welfare Science and Technology Research Project","award":["2016B1002"],"award-info":[{"award-number":["2016B1002"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Angiology"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>Genome-wide association studies have shown that a disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS-9) is associated with the development of atherosclerosis. We assessed the level of ADAMTS-9 in patients with coronary artery disease (CAD) and its severity and prognosis. We selected 666 participants who underwent coronary angiography in our hospital and met the inclusion and exclusion criteria; participants included non-CAD patients, patients with stable angina pectoris (SAP), unstable angina, non-ST-segment elevation myocardial infarction, or ST-segment elevation myocardial infarction. The serum level of ADAMTS-9 was higher in patients with CAD than in non-CAD patients (37.53 \u00b1 8.55 ng\/mL vs 12.04 \u00b1 7.02 ng\/mL, P &lt; .001) and was an independent predictor for CAD (odds ratio = 1.871, 95% CI: 1.533-2.283, P &lt; .001). Subgroup analysis showed that compared with the SAP group, the acute coronary syndrome groups had higher serum levels of ADAMTS-9. In addition, the level of ADAMTS-9 was related to the SYNTAX score (r = 0.523, P &lt; .001). Patients with acute myocardial infarction (AMI) with elevated levels of ADAMTS-9 had a higher risk of major adverse cardiovascular events (MACE) within 12 months than those with lower levels (log-rank = 4.490, P = .034). Plasma ADAMTS-9 levels may be useful for the diagnosis of CAD and as predictors of MACE in AMI patients.<\/jats:p>","DOI":"10.1177\/0003319720979238","type":"journal-article","created":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T08:20:44Z","timestamp":1607934044000},"page":"371-380","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Association Between Plasma ADAMTS-9 Levels and Severity of Coronary Artery Disease"],"prefix":"10.1177","volume":"72","author":[{"given":"Mengqiu","family":"Wei","sequence":"first","affiliation":[{"name":"Intensive Care Unit, Zhongshan People\u2019s Hospital, Zhongshan City, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailin","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Huizhou Municipal Central People\u2019s Hospital, Huizhou City, Guangdong, 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