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An electronic search was conducted based on the PubMed, Ovid, Scopus, Springer, CENTRAL, and Google Scholar databases; 14 randomized controlled trials (RCTs) were included. Our meta-analysis showed a significant reduction in cardiac troponin I (cTnI) levels with trimetazidine compared with controls ( P &lt; .00001) but not in serum creatine kinase-myocardial band levels ( P = .49). There were significantly reduced odds of ischemic ST-T segment changes with trimetazidine ( P = .0.03) but lack of significant difference in the incidence of anginal attacks between the 2 groups ( P = .10). Results also suggest significantly higher LVEF with trimetazidine compared with controls ( P &lt; .00001). Meta-regression analysis indicated no influence of duration of trimetazidine therapy on cTnI levels. The administration of preprocedure trimetazidine may have a role in reducing periprocedural myocardial injury in patients with CAD undergoing PCI. Evidence also suggests that postoperative trimetazidine may improve LVEF in the short term. Lack of high-quality trials and the heterogeneity of studies limit the ability of our analysis to draw strong conclusions. Further well-designed RCTs are required to supplement current evidence.<\/jats:p>","DOI":"10.1177\/0003319720987745","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T04:36:33Z","timestamp":1611203793000},"page":"511-523","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Efficacy of Trimetazidine in Limiting Periprocedural Myocardial Injury in Patients Undergoing Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis"],"prefix":"10.1177","volume":"72","author":[{"given":"Chang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, P. R. 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