{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:27:54Z","timestamp":1777400874393,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T00:00:00Z","timestamp":1618444800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Angiology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:p>This study aimed to determine the efficacy of alprostadil in preventing contrast-induced nephropathy (CIN). Eligible studies were searched using the keywords through the databases of PubMed, Cochrane, Embase, China Biological Medicine Database, China National Knowledge Infrastructure, and Vanfun. Quality evaluation of the included studies was conducted according to international evidence evaluation and recommended Grades of Recommendations Assessment, Development, and Evaluation standards. We included 29 studies with 5623 patients. Compared with hydration, 10 \u00b5g\/d alprostadil or 20 \u00b5g\/d alprostadil plus hydration significantly decreased the incidence of CIN. Compared with hydration, alprostadil plus hydration significantly reduced serum creatinine and blood urea nitrogen at 24, 48, and 72 hours and 7 days after coronary angiography (CAG). Alprostadil (20 \u00b5g\/d) plus hydration significantly decreased serum cystatin versus hydration at 24, 48, and 72 hours after CAG. Compared with hydration, alprostadil plus hydration significantly increased glomerular filtration rate at 24 and 72 hours after CAG. Alprostadil plus hydration significantly decreased neutrophil gelatinase-associated lipocalin levels compared to hydration at 24, 48, and 72 hours after CAG. Alprostadil plus hydration significantly decreased urine macroglobulin versus hydration at 24 and 48 hours after CAG.<\/jats:p>","DOI":"10.1177\/00033197211004412","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T09:03:00Z","timestamp":1618477380000},"page":"878-888","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy of Alprostadil in Preventing Contrast-Induced Nephropathy: A Systematic Review and Meta-Analysis"],"prefix":"10.1177","volume":"72","author":[{"given":"Hongling","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Cardiology, The 8th Medical Center of Chinese PLA General Hospital, Beijing, People\u2019s Republic of China"},{"name":"These authors contributed equally to this paper."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongye","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The 8th Medical Center of Chinese PLA General Hospital, Beijing, People\u2019s Republic of China"},{"name":"These authors contributed equally to this paper."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The 8th Medical Center of Chinese PLA General Hospital, Beijing, People\u2019s Republic of China"},{"name":"These authors contributed equally to this paper."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3726-8943","authenticated-orcid":false,"given":"Jun","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, The 8th Medical Center of Chinese PLA General Hospital, Beijing, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The 8th Medical Center of Chinese PLA General Hospital, Beijing, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuezheng","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The 8th Medical Center of Chinese PLA General Hospital, Beijing, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqi","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The 8th Medical Center of Chinese PLA General Hospital, Beijing, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengbin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The 8th Medical Center of Chinese PLA General Hospital, Beijing, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,4,15]]},"reference":[{"key":"bibr1-00033197211004412","doi-asserted-by":"publisher","DOI":"10.1016\/j.carj.2012.11.002"},{"key":"bibr2-00033197211004412","doi-asserted-by":"publisher","DOI":"10.1111\/joic.12379"},{"key":"bibr3-00033197211004412","doi-asserted-by":"publisher","DOI":"10.1177\/0003319716676173"},{"key":"bibr4-00033197211004412","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0b013e3181d2eed8"},{"key":"bibr5-00033197211004412","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/868321"},{"key":"bibr6-00033197211004412","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2016.3463"},{"key":"bibr7-00033197211004412","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.04.026"},{"key":"bibr8-00033197211004412","doi-asserted-by":"crossref","first-page":"3475","DOI":"10.3760\/cma.j.issn.0366-6999.20123487","volume":"126","author":"Liu WJ","year":"2013","journal-title":"Chin Med J"},{"key":"bibr9-00033197211004412","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-014-0674-5"},{"key":"bibr10-00033197211004412","doi-asserted-by":"crossref","unstructured":"Liang M, Yang S, Fu N. Efficacy of alprostadil in preventing contrast-induced nephropathy in patients undergoing percutaneous coronary intervention: A multicenter prospective randomized controlled trial. 2018; 91:742\u201350.","DOI":"10.1002\/ccd.27353"},{"key":"bibr11-00033197211004412","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-013-0484-1"},{"key":"bibr12-00033197211004412","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-017-1639-2"},{"key":"bibr13-00033197211004412","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2013.1258"},{"key":"bibr14-00033197211004412","doi-asserted-by":"publisher","DOI":"10.1177\/0003319717730942"},{"key":"bibr15-00033197211004412","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/15.1.43"},{"key":"bibr16-00033197211004412","first-page":"62","volume":"52","author":"Dai M","year":"2012","journal-title":"Shandong Medical Journal"},{"key":"bibr17-00033197211004412","first-page":"174","volume":"11","author":"Wang L","year":"2016","journal-title":"China Practical Medicine"},{"key":"bibr18-00033197211004412","first-page":"28","volume":"16","author":"Wang J","year":"2014","journal-title":"Journal of Southeast China National Defence Medical Science"},{"key":"bibr19-00033197211004412","first-page":"34","volume":"36","author":"Zhou D","year":"2013","journal-title":"Chinese Journal of Postgraduates of Medicine"},{"key":"bibr20-00033197211004412","first-page":"1172","volume":"33","author":"Cui J","year":"2012","journal-title":"Guangdong Medical Journal"},{"key":"bibr21-00033197211004412","first-page":"71","author":"Chen L","year":"2017","journal-title":"Diabetes New World"},{"key":"bibr22-00033197211004412","first-page":"2952","volume":"28","author":"Liu W","year":"2012","journal-title":"The Journal of Practical Medicine"},{"key":"bibr23-00033197211004412","first-page":"1816","volume":"25","author":"Li Y","year":"2018","journal-title":"Chinese Journal of Primary Medicine and Pharmacy"},{"key":"bibr24-00033197211004412","first-page":"366","volume":"21","author":"Li W","year":"2019","journal-title":"Chinese Journal of Geriatric Heart Brain and Vessel Diseases"},{"key":"bibr25-00033197211004412","first-page":"9","volume":"43","author":"Li J","year":"2016","journal-title":"Chinese Journal of Practical Medicine"},{"key":"bibr26-00033197211004412","volume":"19","author":"Ban X","year":"2015","journal-title":"Anhui Medical and Pharmaceutical Journal"},{"key":"bibr27-00033197211004412","first-page":"49","volume":"55","author":"Su C","year":"2015","journal-title":"Shandong Medical Journal"},{"key":"bibr28-00033197211004412","first-page":"154","volume":"15","author":"Wu Y","year":"2016","journal-title":"Chinese Journal of Difficult and Complicated Cases"},{"key":"bibr29-00033197211004412","first-page":"1386","volume":"15","author":"Ye Y","year":"2006","journal-title":"Chinese Journal of New Drugs"},{"key":"bibr30-00033197211004412","first-page":"1128","volume":"29","author":"Xu R","year":"2012","journal-title":"J Clin Med"},{"key":"bibr31-00033197211004412","first-page":"772","volume":"25","author":"Zheng J","year":"2015","journal-title":"Zhejiang Journal of Integrated Traditional Chinese and Western Medicine"},{"key":"bibr32-00033197211004412","first-page":"245","volume":"21","author":"Ma N","year":"2019","journal-title":"Chinese Journal of Geriatric Heart Brain and Vessel Diseases"},{"key":"bibr33-00033197211004412","first-page":"2799","volume":"33","author":"Xu R","year":"2012","journal-title":"Guangdong Medical Journal"},{"key":"bibr34-00033197211004412","first-page":"3924","volume":"48","author":"Wang L","year":"2019","journal-title":"Chongqing Medicine"},{"key":"bibr35-00033197211004412","first-page":"5052","volume":"25","author":"Cai Q","year":"2014","journal-title":"Modern Diagnosis and Treatment"},{"key":"bibr36-00033197211004412","first-page":"597","volume":"21","author":"Liu L","year":"2011","journal-title":"Chinese Journal of Hemorheology"},{"key":"bibr37-00033197211004412","doi-asserted-by":"publisher","DOI":"10.1177\/0003319719825597"}],"container-title":["Angiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00033197211004412","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00033197211004412","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00033197211004412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:19:58Z","timestamp":1777371598000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00033197211004412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,15]]},"references-count":37,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1177\/00033197211004412"],"URL":"https:\/\/doi.org\/10.1177\/00033197211004412","relation":{},"ISSN":["0003-3197","1940-1574"],"issn-type":[{"value":"0003-3197","type":"print"},{"value":"1940-1574","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,15]]}}}