{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:28:05Z","timestamp":1777400885409,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T00:00:00Z","timestamp":1617753600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Angiology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Nonalcoholic fatty liver disease (NAFLD) is the most common liver pathology in the developed world. Nonalcoholic fatty liver disease is associated with a higher risk of cardiovascular disease. We investigated the impact of ranolazine on liver tests in patients with NAFLD and coronary artery disease (CAD). Patients who had established CAD and NAFLD (as assessed by raised serum transaminase activity, sonographic criteria, and the absence of any other obvious liver disease) were allocated to \u201con ranolazine\u201d (n = 40) or \u201cnot on ranolazine\u201d (n = 35) groups. Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured in all patients at baseline and at the end of the study. After 6 months of ranolazine treatment, both ALT and AST activities were significantly lower in patients in the \u201con ranolazine\u201d group compared with \u201cnot on ranolazine\u201d patients (change from baseline: ALT, \u221211.0 \u00b1 1.7 IU\/L, P &lt; .001; AST, \u22125.2 \u00b1 1.9 IU\/L, P =.009). In conclusion, the present study showed that treatment with ranolazine for 6 months led to a significant reduction in the activities of both serum aminotransferases in patients with stable CAD and NAFLD.<\/jats:p>","DOI":"10.1177\/00033197211005590","type":"journal-article","created":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T04:21:41Z","timestamp":1617769301000},"page":"73-78","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of the Impact of Ranolazine Treatment on Liver Function Tests in Patients With Coronary Heart Disease and Nonalcoholic Fatty Liver Disease"],"prefix":"10.1177","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7516-9113","authenticated-orcid":false,"given":"Kerim","family":"Esenbo\u011fa","sequence":"first","affiliation":[{"name":"Ankara University Faculty of Medicine, Department of Cardiology, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0817-8906","authenticated-orcid":false,"given":"Alparslan","family":"Kurtul","sequence":"additional","affiliation":[{"name":"Hatay Mustafa Kemal University Faculty of Medicine, Department of Cardiology, Hatay, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00fcseyin","family":"Nazman","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sivas Numune State Hospital, Sivas, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cemre G\u00fcl","family":"Tekin","sequence":"additional","affiliation":[{"name":"Ankara University Faculty of Medicine, Department of Cardiology, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nil","family":"\u00d6zy\u00fcnc\u00fc","sequence":"additional","affiliation":[{"name":"Ankara University Faculty of Medicine, Department of Cardiology, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T\u00fcrkan Seda","family":"Tan","sequence":"additional","affiliation":[{"name":"Ankara University Faculty of Medicine, Department of Cardiology, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eralp","family":"Tutar","sequence":"additional","affiliation":[{"name":"Ankara University Faculty of Medicine, Department of Cardiology, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sibel Tekin","family":"Turhan","sequence":"additional","affiliation":[{"name":"Ankara University Faculty of Medicine, Department of Cardiology, Ankara, 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