{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:28:15Z","timestamp":1777400895649,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T00:00:00Z","timestamp":1623110400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Tianjin Municipal Health and Family Planning Commission"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Angiology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>The Mehran risk score (MRS) was used to classify patients with coronary heart disease and evaluate the preventive effect of alprostadil on contrast-induced nephropathy (CIN) after percutaneous coronary intervention. The patients (n = 1146) were randomized into an alprostadil and control group and then divided into 3 groups on the basis of the MRS: low-risk, moderate-risk, and high-risk groups. The primary end point was the occurrence of CIN (alprostadil + hydration vs simple hydration treatment); secondary end points included serum creatinine, blood urea nitrogen, creatinine clearance rate, cystatin C, interleukin-6, C-reactive protein, proteinuria, and differences in the incidence of major adverse events. In the low-risk, moderate-risk, and high-risk groups, the incidence of CIN in the control and alprostadil group was 2.9 versus 2.6% ( P = .832), 11.4 versus 4.9% ( P = .030), 19.1 versus 7.7% ( P = .041), respectively. Multivariate logistic regression analysis showed that alprostadil treatment was a favorable protective factor for moderate-risk and high-risk CIN patients (OR = 0.343, 95% CI: 0.124-0.951, P = .040). Alprostadil can be used as a preventive treatment for moderate- and high-risk CIN patients classified by the MRS. The reduction of CIN by alprostadil may be related to an anti-inflammatory effect.<\/jats:p>","DOI":"10.1177\/00033197211015540","type":"journal-article","created":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T05:02:28Z","timestamp":1623128548000},"page":"33-41","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["The Preventive Effect of Alprostadil on the Contrast-Induced Nephropathy of Coronary Heart Disease Treated by Percutaneous Coronary Intervention in Moderate and High-Risk Population Stratified by Mehran Score"],"prefix":"10.1177","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4099-6693","authenticated-orcid":false,"given":"Xiaogang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Tianjin Chest Hospital, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2039-9373","authenticated-orcid":false,"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tianjin Chest Hospital, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tianjin Chest Hospital, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Graduate School of Tianjin Medical University, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9083-5575","authenticated-orcid":false,"given":"Shicheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tianjin Chest Hospital, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naikuan","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tianjin Chest Hospital, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,6,8]]},"reference":[{"key":"bibr1-00033197211015540","doi-asserted-by":"publisher","DOI":"10.1177\/0003319717730942"},{"key":"bibr2-00033197211015540","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.04.055"},{"key":"bibr3-00033197211015540","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31814-7"},{"key":"bibr4-00033197211015540","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.04.007"},{"key":"bibr5-00033197211015540","doi-asserted-by":"crossref","first-page":"e0129747","DOI":"10.1371\/journal.pone.0129747","volume":"10","author":"Wu Z","year":"2015","journal-title":"PLoS One"},{"key":"bibr6-00033197211015540","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2016.3463"},{"key":"bibr7-00033197211015540","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000479"},{"key":"bibr8-00033197211015540","doi-asserted-by":"publisher","DOI":"10.1159\/000443936"},{"key":"bibr9-00033197211015540","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2015.05.007"},{"key":"bibr10-00033197211015540","doi-asserted-by":"publisher","DOI":"10.14740\/cr939"},{"key":"bibr11-00033197211015540","doi-asserted-by":"publisher","DOI":"10.7326\/M15-1456"},{"key":"bibr12-00033197211015540","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2013.1258"},{"key":"bibr13-00033197211015540","doi-asserted-by":"publisher","DOI":"10.1177\/0003319719825597"},{"key":"bibr14-00033197211015540","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2017.03.003"},{"key":"bibr15-00033197211015540","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.04.068"},{"key":"bibr16-00033197211015540","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-012-0363-1"},{"issue":"147","key":"bibr17-00033197211015540","volume":"8","author":"Chen YH","year":"2019","journal-title":"J Clin Med"},{"key":"bibr18-00033197211015540","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10091485"},{"key":"bibr19-00033197211015540","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-011-2225-0"},{"key":"bibr20-00033197211015540","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2019.06.05"},{"key":"bibr21-00033197211015540","doi-asserted-by":"publisher","DOI":"10.1016\/S1995-7645(14)60157-7"},{"key":"bibr22-00033197211015540","doi-asserted-by":"publisher","DOI":"10.1097\/00045391-200105000-00004"},{"key":"bibr23-00033197211015540","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000011416"},{"key":"bibr24-00033197211015540","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112885"},{"key":"bibr25-00033197211015540","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.27353"},{"key":"bibr26-00033197211015540","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.28.3.372"},{"key":"bibr27-00033197211015540","doi-asserted-by":"publisher","DOI":"10.1097\/MCA.0000000000000294"},{"key":"bibr28-00033197211015540","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1992.426"},{"key":"bibr29-00033197211015540","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2006.07.016"},{"key":"bibr30-00033197211015540","first-page":"129","volume":"21","author":"Hudzik B","year":"2010","journal-title":"Eur Cytokine Netw"},{"key":"bibr31-00033197211015540","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.05.099"}],"container-title":["Angiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00033197211015540","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00033197211015540","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00033197211015540","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:20:01Z","timestamp":1777371601000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00033197211015540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,8]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1177\/00033197211015540"],"URL":"https:\/\/doi.org\/10.1177\/00033197211015540","relation":{},"ISSN":["0003-3197","1940-1574"],"issn-type":[{"value":"0003-3197","type":"print"},{"value":"1940-1574","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,8]]}}}