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In this study, the relative expression levels of circulating miR-221\/222 in patients with ACS (n = 267) and controls (n = 71) were compared by real-time fluorescence quantitative-polymerase chain reaction (RT-qPCR). The ACS group was further divided into unstable angina pectoris (UA) group (n = 191) and acute myocardial infarction (AMI) group (n = 76). Significant upregulation of circulating miR-221\/222 was observed in ACS. A positive linear correlation between circulating miR-221\/222 and Gensini scores was demonstrated. The area under the curve (AUC) of circulating miR-221\/222 in the diagnosis of coronary artery stenosis \u226550% was 0.605 and 0.643, respectively. The circulating miRNA-221\/222 expression levels in ACS patients were elevated and positively associated with the severity of the coronary artery lesions. Circulating miR-221\/222 may be novel biomarkers for the diagnosis of coronary artery stenosis \u226550% and the occurrence of ACS.<\/jats:p>","DOI":"10.1177\/00033197211034286","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T22:14:13Z","timestamp":1627683253000},"page":"579-587","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Associations of Circulating microRNA-221 and 222 With the Severity of Coronary Artery Lesions in Acute Coronary Syndrome Patients"],"prefix":"10.1177","volume":"73","author":[{"given":"Xin","family":"Yu","sequence":"first","affiliation":[{"name":"The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-feng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Yantai Yuhuangding Hospital, Yantai, Shandong, P.R. 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