{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:29:28Z","timestamp":1777400968596,"version":"3.51.4"},"reference-count":43,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T00:00:00Z","timestamp":1615248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"2020 Li Ka Shing Foundation Cross-Disciplinary Research Grant","award":["L1111 2004"],"award-info":[{"award-number":["L1111 2004"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Angiology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:p>The association between anemia and Takotsubo cardiomyopathy (TCM) has not been well studied. To assess the effect of anemia on patients hospitalized with TCM, we identified 4733 patients with a primary diagnosis of TCM from the 2016 to 2018 National Inpatient Sample (NIS) database (the United States) using the International Classification of Diseases, 10th edition, Clinical Modification ( ICD-10-CM) code. Of these, 603 (12.7%) patients had a comorbidity of anemia and 4130 did not. After propensity score matching, we compared the in-hospital outcomes between the 2 groups (anemia vs nonanemia, n = 594 vs 1137). Patients with TCM with anemia had significantly higher rates of in-hospital complications, including cardiogenic shock (11.4% vs 4.0%, P &lt; .001), ventricular arrhythmia (6.6% vs 3.6%, P = .008), acute kidney injury (22.7% vs 13.1%, P &lt; .001), acute respiratory failure (22.6% vs 13.1%, P &lt; .001), longer length of hospital stay (5.6 \u00b1 5.8 days vs 3.6 \u00b1 3.6 days, P &lt; .001), and higher total charges (US$79 586 \u00b1 10 2436 vs US$50 711 \u00b1 42 639, P &lt; .001). In conclusion, patients with anemia who were admitted for TCM were associated with a higher incidence of in-hospital complications compared with those without anemia.<\/jats:p>","DOI":"10.1177\/0003319721999492","type":"journal-article","created":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T04:51:07Z","timestamp":1615265467000},"page":"842-849","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Anemia Is Associated With Poor Clinical Outcomes in Hospitalized Patients With Takotsubo Cardiomyopathy"],"prefix":"10.1177","volume":"72","author":[{"given":"Xiaojia","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengyang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medicine, Saint Vincent Hospital, Worcester, MA, the United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Medicine, Yale New Haven Health-Greenwich Hospital, Greenwich, CT, the United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Mathematical Sciences, Worcester Polytechnic Institute, Worcester, MA, the United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7797-600X","authenticated-orcid":false,"given":"Bin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, People\u2019s Republic of China"},{"name":"Clinical Research Center, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,3,9]]},"reference":[{"key":"bibr1-0003319721999492","first-page":"56","volume-title":"Clinical Aspect of Myocardial Injury: From Ischemia to Heart Failure","author":"Sato H","year":"1990"},{"key":"bibr2-0003319721999492","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.04.010"},{"key":"bibr3-0003319721999492","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2010.01.009"},{"key":"bibr4-0003319721999492","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.11.008"},{"key":"bibr5-0003319721999492","first-page":"18","author":"Lyon AR","year":"2016","journal-title":"Eur J Heart Fail"},{"key":"bibr6-0003319721999492","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy076"},{"key":"bibr7-0003319721999492","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1406761"},{"key":"bibr8-0003319721999492","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.06.016"},{"key":"bibr9-0003319721999492","doi-asserted-by":"publisher","DOI":"10.1177\/0003319719830011"},{"key":"bibr10-0003319721999492","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22999"},{"key":"bibr11-0003319721999492","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S282009"},{"key":"bibr12-0003319721999492","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-2609"},{"key":"bibr13-0003319721999492","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2018.04.139"},{"key":"bibr14-0003319721999492","author":"Li P","year":"2020","journal-title":"ESC Heart Fail"},{"key":"bibr15-0003319721999492","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2018.09.098"},{"key":"bibr16-0003319721999492","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S267289"},{"key":"bibr17-0003319721999492","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-05-1812"},{"key":"bibr18-0003319721999492","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-09-0184"},{"key":"bibr19-0003319721999492","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.06.088"},{"key":"bibr20-0003319721999492","first-page":"5","author":"Mamas MA","year":"2016","journal-title":"J Am Heart Assoc"},{"key":"bibr21-0003319721999492","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2019.08.004"},{"key":"bibr22-0003319721999492","unstructured":"HCUP Nationwide Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality, Rockville, MD, https:\/\/www.hcup-us.ahrq.gov\/nisoverview.jsp. 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