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Methods: A total of 723 participants were enrolled: 67 healthy subjects, 214 patients with common iliac artery occlusions, 224 patients with popliteal artery occlusions, and 218 patients with femoral artery occlusions. We measured oxidative stress biomarkers (malondialdehyde [MDA], F2-isoprostane [F2-isoP], total oxidant status [TOS], and ischemia-modified albumin [IMA]) and the expressions of molecules in mimecan (MIME)\/nuclear factor kappa B (NF-\u03baB)\/P53\/Toll-like receptor 4 (TLR4) signaling pathway in older patients with multiple peripheral artery occlusions. Results: The levels of MDA, F2-isoP, TOS, IMA, MIME, NF-\u03baB, P53, and TLR4 were increased in the single-site peripheral artery occlusive group when compared with healthy controls ( P &lt; .001) and were further increased in the multiple-site peripheral artery occlusive group compared with the single-site peripheral artery occlusive group ( P &lt; .001). Conclusion: Oxidative stress may promote inflammatory signaling pathways and lead to multiple peripheral artery occlusions in elderly patients.<\/jats:p>","DOI":"10.1177\/00033197221111860","type":"journal-article","created":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T10:22:53Z","timestamp":1656930173000},"page":"472-487","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Oxidative Stress and Inflammation Markers Associated with Multiple Peripheral Artery Occlusions in Elderly Patients"],"prefix":"10.1177","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5178-8059","authenticated-orcid":false,"given":"Xia","family":"Li","sequence":"first","affiliation":[{"name":"Xiamen Road Branch Hospital, The Affiliated Huaian Hospital of Xuzhou Medical University, Huaian, 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