{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:33:56Z","timestamp":1792787636487,"version":"4.5.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T00:00:00Z","timestamp":1657756800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"The project of basic frontier research of the Science and Technology Bureau of Wuhan","award":["2020020601012323"],"award-info":[{"award-number":["2020020601012323"]}]},{"name":"The project of basic frontier research of the Science and Technology Bureau of Wuhan","award":["2022020801020581"],"award-info":[{"award-number":["2022020801020581"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Angiology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:p>\n                    The association between white blood cell (WBC) count and arterial stiffness in patients with hypertension is not well-documented. We aimed to examine the relationships of total WBC count with arterial stiffness and risk of macrovascular damage in hypertensive patients. A total of 631 hypertensive adults (mean age: 65.6\u00a0years) were included in the present study. Arterial stiffness was determined by brachial-ankle pulse wave velocity (baPWV) and ankle-brachial index (ABI). Macrovascular damage was defined as baPWV &gt;1.8\u00a0m\/s or ABI &lt;.9. The dose-response associations were assessed by multivariate linear or logistic regression models. After multivariate adjustments, we observed a dose-response relationship between increasing total WBC count and arterial stiffness. Participants in the highest tertile of total WBC count showed a significantly elevated baPWV (\u03b2 = .088; 95% CI: .021, .154; P\n                    <jats:sub>trend<\/jats:sub>\n                    = .010) and reduced ABI (\u03b2 = \u2212.027; 95% CI: \u2212.046, \u2212.008; P\n                    <jats:sub>trend<\/jats:sub>\n                    = .005), as compared with those in the first tertile. The association was similar in different subgroups. In addition, elevated total WBC count was related to a greater risk of macrovascular damage, as indicated by baPWV &gt;1.8\u00a0m\/s (OR = 1.86; 95% CI: 1.15, 2.99, comparing the extreme tertiles). Our data suggest that elevated total WBC count was related to arterial stiffness among individuals with hypertension.\n                  <\/jats:p>","DOI":"10.1177\/00033197221115566","type":"journal-article","created":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T09:34:09Z","timestamp":1657791249000},"page":"657-663","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Total White Blood Cell Count is Associated with Arterial Stiffness Among Hypertensive Patients"],"prefix":"10.1177","volume":"74","author":[{"given":"Min","family":"Huang","sequence":"first","affiliation":[{"name":"Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fajiu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Jianghan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, The No. 969 Hospital of Joint Logistic Support Force of Chinese People\u2019s Liberation Army, Huhehot, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Jianghan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Jianghan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanjuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Jianghan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Jianghan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinnan","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Jianghan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Affiliated Hospital of Jianghan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4984-5146","authenticated-orcid":false,"given":"Bingzhu","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Jianghan University, Wuhan, 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