{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T08:08:39Z","timestamp":1787731719497,"version":"build-2784847793"},"reference-count":43,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T00:00:00Z","timestamp":1662422400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Angiology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:p>\n                    While TAVI is widely used, optimal medical therapy to reduce the mortality rate after transcatheter aortic valve implantation (TAVI) is still unclear. We performed a systematic review and meta-analysis to evaluate the impact of statins on mortality following TAVI. Present systematic review of the literature was performed using Medline, Embase, Scopus, and Web of Science; all studies reported all-cause mortality in patients who underwent TAVI and received or did not receive statin therapy. Data were analyzed using random-effects models. Seventeen articles (21\u00a0380 patients) were included in the meta-analysis. Statin therapy was associated with a reduction of all-cause mortality (Hazard ratio [HR] = .78, 95% Confidence interval [CI] .68\u2013.89, P &lt; .001). Moderate between-study heterogeneity was observed (I\n                    <jats:sup>2<\/jats:sup>\n                    = 45.2). High-intensity statin therapy was more effective than low or moderate intensity statin therapy in reduction of all-cause mortality (Risk ratio [RR] = .62, 95% CI 0.45\u2013.85, P = .003, I\n                    <jats:sup>2<\/jats:sup>\n                    = .0). Statin therapy could reduce the mid-term all-cause mortality rate following TAVI. However, all included studies were observational and, therefore, randomized controlled trials are still needed to assess the effect of statin therapy on mortality after TAVI.\n                  <\/jats:p>","DOI":"10.1177\/00033197221124778","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T14:25:05Z","timestamp":1662474305000},"page":"611-623","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Statins and Mortality of Patients After Transcatheter Aortic Valve Implantation: A Systematic Review and Meta-analysis"],"prefix":"10.1177","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5937-6390","authenticated-orcid":false,"given":"Pourya","family":"Yarahmadi","sequence":"first","affiliation":[{"name":"School of Medicine, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Kabiri","sequence":"additional","affiliation":[{"name":"School of Medicine, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Mohammad","family":"Forouzannia","sequence":"additional","affiliation":[{"name":"School of Medicine, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Yousefifard","sequence":"additional","affiliation":[{"name":"Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,9,6]]},"reference":[{"key":"bibr1-00033197221124778","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000047200.36165.B8"},{"key":"bibr2-00033197221124778","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy244"},{"key":"bibr3-00033197221124778","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-019-0254-6"},{"key":"bibr4-00033197221124778","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.18077"},{"key":"bibr5-00033197221124778","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2021.06.020"},{"key":"bibr6-00033197221124778","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezt181"},{"key":"bibr7-00033197221124778","doi-asserted-by":"publisher","DOI":"10.1517\/14740330903188413"},{"key":"bibr8-00033197221124778","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-018-4586-x"},{"key":"bibr9-00033197221124778","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-044319"},{"key":"bibr10-00033197221124778","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.011529"},{"key":"bibr11-00033197221124778","first-page":"e6030","volume":"11","author":"Herron 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