{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:17:25Z","timestamp":1790201845037,"version":"4.1.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T00:00:00Z","timestamp":1663027200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Angiology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:p>Women with a history of venous thromboembolisms (VTEs) and\/or thrombophilia are at increased risk of VTE during pregnancy. We analysed our cohort of such women who were treated with a prophylactic doses of dalteparin. 152 pregnant women with 179 pregnancies were classified into 3 groups: (1) previous VTE without thrombophilia (122 pregnancies); (2) previous VTE with thrombophilia (26 pregnancies) and (3) thrombophilia only (31 pregnancies). They were treated with prophylactic dalteparin in the prepartum and postpartum periods or only in the postpartum period. Occurrences of symptomatic VTE and bleeding episodes were followed, as well as dalteparin discontinuation and anti-Xa activity. Symptomatic deep vein thrombosis occurred in 4 women (2.2%) with 2 episodes in group 1 (in the postpartum period) and 2 episodes in group 2 (one in the prepartum and another in the postpartum period). Seven episodes (3.9%) of minor bleeding occurred. Dalteparin was not stopped in any women. Anti-Xa levels were within the prophylactic range. Our real-world data show a low incidence of thrombosis and minor bleeding in pregnant women treated with prophylactic dalteparin. The incidence of recurrent VTE was lower than that reported in women with similar risk, but without prophylactic anticoagulation.<\/jats:p>","DOI":"10.1177\/00033197221126244","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T16:52:27Z","timestamp":1663087947000},"page":"783-789","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Prophylactic Dose of Dalteparin in Pregnant Women With History of Venous Thromboembolisms and\/or Thrombophilia: Real-World Data"],"prefix":"10.1177","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5607-627X","authenticated-orcid":false,"given":"Petra","family":"Novak","sequence":"first","affiliation":[{"name":"Department of Perioperative Medicine, General Hospital Murska Sobota, Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Novak","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Perioperative Intensive Care and Pain Management, General Hospital Novo Mesto, Novo Mesto, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi\u0161o","family":"\u0160abovi\u0107","sequence":"additional","affiliation":[{"name":"Department for Vascular Disorders, University Medical Centre Ljubljana, Ljubljana, Slovenia"},{"name":"Medical Faculty, University of Ljubljana, Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matija","family":"Kozak","sequence":"additional","affiliation":[{"name":"Department for Vascular Disorders, University Medical Centre Ljubljana, Ljubljana, Slovenia"},{"name":"Medical Faculty, University of Ljubljana, Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,9,13]]},"reference":[{"key":"bibr1-00033197221126244","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j4452"},{"key":"bibr2-00033197221126244","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(16)34240-2"},{"key":"bibr3-00033197221126244","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-01-0149"},{"key":"bibr4-00033197221126244","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200011163432002"},{"key":"bibr5-00033197221126244","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01307.x"},{"key":"bibr6-00033197221126244","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06317.x"},{"key":"bibr7-00033197221126244","doi-asserted-by":"publisher","DOI":"10.1186\/s12959-020-00251-w"},{"key":"bibr8-00033197221126244","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002114"},{"key":"bibr9-00033197221126244","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018024802"},{"key":"bibr10-00033197221126244","volume-title":"Reducing the Risk of Venous Thromboembolism During Pregnancy and the Puerperium. RCOG Green-Top Guideline No. 37a 2 of 40","author":"Royal College of Obstetricians and Gynaecologists","year":"2015"},{"key":"bibr11-00033197221126244","volume-title":"Venous Thromboembolism in Over 16s: Reducing the Risk of Hospital-Acquired Deep Vein Thrombosis or Pulmonary Embolism (NG89) NICE Guideline","year":"2018"},{"key":"bibr12-00033197221126244","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2015.11.026"},{"key":"bibr13-00033197221126244","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.15150"},{"key":"bibr14-00033197221126244","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.12.057"},{"key":"bibr15-00033197221126244","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2017.1.160"},{"key":"bibr16-00033197221126244","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15166"},{"issue":"3","key":"bibr17-00033197221126244","first-page":"CD001689","volume":"3","author":"Middleton P","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"bibr18-00033197221126244","first-page":"22","volume":"4","author":"Romano M","year":"2010","journal-title":"J Prenat Med"},{"key":"bibr19-00033197221126244","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14576"},{"key":"bibr20-00033197221126244","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13140"},{"key":"bibr21-00033197221126244","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-015-1309-0"},{"key":"bibr22-00033197221126244","doi-asserted-by":"publisher","DOI":"10.4081\/hr.2015.5844"},{"key":"bibr23-00033197221126244","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2017.1419179"},{"key":"bibr24-00033197221126244","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14568"},{"key":"bibr25-00033197221126244","doi-asserted-by":"publisher","DOI":"10.1182\/hematology.2021000291"}],"container-title":["Angiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00033197221126244","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00033197221126244","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00033197221126244","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:21:10Z","timestamp":1777371670000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/00033197221126244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,13]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1177\/00033197221126244"],"URL":"https:\/\/doi.org\/10.1177\/00033197221126244","relation":{},"ISSN":["0003-3197","1940-1574"],"issn-type":[{"value":"0003-3197","type":"print"},{"value":"1940-1574","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,13]]}}}