{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:01:32Z","timestamp":1787018492017,"version":"build-2736575974"},"reference-count":41,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T00:00:00Z","timestamp":1680480000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Mu\u00c3&ldquour;\u00c2\u0178la S\u00c3&ldquour;\u00c2\u00b1tk\u00c3&ldquour;\u00c2\u00b1 Ko\u00c3&z.hfl;\u00c2\u00a7man University Research Support and Funding Office","award":["Project No: 20\/103\/01\/3\/4"],"award-info":[{"award-number":["Project No: 20\/103\/01\/3\/4"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Angiology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:p>The present study evaluated the use of endocan, interleukin-17 (IL-17), and thrombospondin-4 (TSP-4) blood levels as potential biomarkers for the diagnosis and follow-up of peripheral arterial disease (PAD). Patients with PAD (Rutherford categories I, II, and III) who were admitted between March 2020 and March 2022 for cardiovascular surgery or outpatient clinic follow-up were included. The patients ( n = 60) were divided into 2 groups: medical treatment ( n = 30) and surgical treatment ( n = 30). In addition, a control group ( n = 30) was created for comparison. Endocan, IL-17, and TSP-4 blood levels were measured at the time of diagnosis and at the first month after treatment. Endocan and IL-17 values were found to be significantly higher in both groups that underwent medical (259.7 \u00b1 46\u00a0pg\/mL, 63.7 \u00b1 16.6\u00a0pg\/mL) and surgical (290.3 \u00b1 84.5\u00a0pg\/mL, 66.4 \u00b1 19.6\u00a0pg\/mL) treatment than the control group (187.4 \u00b1 34.5\u00a0pg\/mL, 56.5 \u00b1 7.2\u00a0pg\/mL P &lt; .001). Tsp-4 value was found to be significantly higher only in the surgical treatment group (15 \u00b1 4.3\u00a0ng\/mL) than the control group (12.9 \u00b1 1.4\u00a0ng\/mL P &lt; .05). The decreases in endocan, IL-17, and TSP-4 levels at the first month of treatment in both groups were also significant ( P &lt; .001). A combination of classical and these new biomarkers could be included in PAD screening, early diagnosis, severity determination, and follow-up protocols in order to provide effective assessment in clinical practice.<\/jats:p>","DOI":"10.1177\/00033197231166492","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T08:55:10Z","timestamp":1680512110000},"page":"631-639","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["New Biomarkers (Endocan, Interleukin-17, and Thrombospondin-4) for the Diagnosis, Assessment of Severity, and Follow-Up of Peripheral Arterial Disease"],"prefix":"10.1177","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6035-1123","authenticated-orcid":false,"given":"Serkan","family":"Yazman","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, Mu\u011fla S\u0131tk\u0131 Ko\u00e7man University Faculty of Medicine, Mugla, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burak Can","family":"Depboylu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Mu\u011fla S\u0131tk\u0131 Ko\u00e7man University Faculty of Medicine, Mugla, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ercan","family":"Saruhan","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Mu\u011fla S\u0131tk\u0131 Ko\u00e7man University Faculty of Medicine, Mugla, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Utku","family":"Cenikli","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mu\u011fla S\u0131tk\u0131 Ko\u00e7man University Faculty of Medicine, Mugla, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bu\u011fra","family":"Harmandar","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Mu\u011fla S\u0131tk\u0131 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