{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:36:59Z","timestamp":1777401419615,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:00:00Z","timestamp":1705449600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"National Science Foundation for Scientists of China","award":["82271993"],"award-info":[{"award-number":["82271993"]}]},{"name":"National Science Foundation for Scientists of China","award":["81871354"],"award-info":[{"award-number":["81871354"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Angiology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:p>\n                    We aimed to test whether computed tomography (CT)-diagnosed Non-Alcoholic Fatty Liver Disease (NAFLD) is a risk factor for cerebrovascular symptoms in patients with suspected atherosclerotic disease. A total of 550 patients (mean age 65.2 \u00b1 8.8\u00a0years, 370 males) with carotid plaques who underwent carotid computed tomographic angiography (CTA) and unenhanced abdominal CT were retrospectively analyzed. NAFLD was diagnosed by abdominal CT. Carotid CTA assessed the presence of carotid artery stenosis or plaque. The relationship between NAFLD and cerebrovascular symptoms was analyzed using generalized estimating equations and receiver operating characteristic (ROC) analysis. The prevalence of NAFLD was significantly higher in symptomatic patients (76.5 vs 9.8%;\n                    <jats:italic>P<\/jats:italic>\n                    &lt; .001). After adjusting for several confounding factors (e.g., hypertension and hyperlipidemia), univariate and multivariate logic regression analysis revealed that NAFLD was still strongly associated with cerebrovascular symptoms (odds ratio, 22.81; 95% CI 13.03\u201339.93;\n                    <jats:italic>P<\/jats:italic>\n                    &lt; .001). ROC analysis showed that the area under the curve for discriminating symptomatic and asymptomatic plaques using NAFLD measurements was 0.833, with a sensitivity of 76.5% and a specificity of 90.2%. NAFLD is strongly associated with an increased risk of cerebrovascular symptoms. It may be an important predictor of symptomatic carotid plaque and cerebrovascular symptoms.\n                  <\/jats:p>","DOI":"10.1177\/00033197241227501","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T13:26:26Z","timestamp":1705497986000},"page":"546-553","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["CT-Diagnosed Non-Alcoholic Fatty Liver Disease as a Risk Predictor of Symptomatic Carotid Plaque and Cerebrovascular Symptoms"],"prefix":"10.1177","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2533-0485","authenticated-orcid":false,"given":"Tianqi","family":"Xu","sequence":"first","affiliation":[{"name":"Cheeloo College of Medicine, Shandong University, Jinan, China"},{"name":"Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Physical Examination Center, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Chang","sequence":"additional","affiliation":[{"name":"Jinan Vocational College of Nursing, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sha","family":"Li","sequence":"additional","affiliation":[{"name":"Cheeloo College of Medicine, Shandong University, Jinan, China"},{"name":"Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingxuan","family":"Jiao","sequence":"additional","affiliation":[{"name":"Cheeloo College of Medicine, Shandong University, Jinan, China"},{"name":"Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ximing","family":"Wang","sequence":"additional","affiliation":[{"name":"Cheeloo College of Medicine, Shandong University, Jinan, China"},{"name":"Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,1,17]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.241797"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30035-3"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1144248"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccl.2014.09.001"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2012.10.088"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000441094"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5488"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx095"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31150"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006205-200702000-00002"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.06.001"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29367"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.06.012"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25593"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A6403"},{"key":"e_1_3_4_17_2","first-page":"811","article-title":"The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association","volume":"107","author":"Chalasani N","year":"2012","unstructured":"Chalasani N, Younossi Z, Lavine JE, Diehl AM, Brunt EM, Cusi K, et al. The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. 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