{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T23:21:54Z","timestamp":1784071314949,"version":"3.55.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:00:00Z","timestamp":1707091200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:00:00Z","timestamp":1707091200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100005788","name":"Medizinische Universit\u00e4t Wien","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005788","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Angiology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:p>\n                    Trefoil factor 3 (TFF3) has been studied in processes leading to atherosclerosis. Data are scarce in manifest disease and missing in peripheral artery disease (PAD). This study aims to elucidate TFF3 with disease stages, degrees of atherosclerosis, and outcomes. TFF3 was measured in serum in 364 PAD patients without critical limb ischemia and mild to moderate chronic kidney disease (CKD). Mortality data were retrieved from the Austrian central death registry (median observation 9.6\u00a0years). Survival analyses were performed using Cox regression and the Kaplan\u2013Meier method. A negative association between ankle-brachial index and TFF3 (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .001) was observed, while levels were similar in asymptomatic and symptomatic PAD. TFF3 increased with history of cardiovascular and cerebrovascular disease (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .001). TTF3 was associated with the estimated glomerular filtration rate (R = \u22120.617,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .001) and urinary albumin-creatinine ratio (R = 0.229,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .001). One SD increase in TFF3 showed a worsening in all-cause mortality (hazard ratio 1.68, CI 1.37\u20132.05) which persisted after multiple adjustment for cardiovascular risk, inflammatory, and angiogenetic markers (hazard ratio 1.35, CI 1.01\u20131.81). This study is the first to link TFF3 with both disease markers and outcomes in PAD. TFF3 demonstrated associations with renal function, PAD severity measured by ankle-brachial index, and additional atherosclerotic burden in PAD.\n                  <\/jats:p>","DOI":"10.1177\/00033197241230973","type":"journal-article","created":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T03:52:24Z","timestamp":1707105144000},"page":"409-415","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Serum Trefoil Factor-3 Predicts Survival in Peripheral Artery Disease"],"prefix":"10.1177","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2594-5102","authenticated-orcid":false,"given":"Gerfried","family":"Pesau","sequence":"first","affiliation":[{"name":"Division of Angiology, Department of Internal Medicine II, Medical University Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Zierfuss","sequence":"additional","affiliation":[{"name":"Division of Angiology, Department of Internal Medicine II, Medical University Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9704-1452","authenticated-orcid":false,"given":"Clemens","family":"Hoebaus","sequence":"additional","affiliation":[{"name":"Division of Angiology, Department of Internal Medicine II, Medical University Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renate","family":"Koppensteiner","sequence":"additional","affiliation":[{"name":"Division of Angiology, Department of Internal Medicine II, Medical University Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerit-Holger","family":"Schernthaner","sequence":"additional","affiliation":[{"name":"Division of Angiology, Department of Internal Medicine II, Medical University Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,2,5]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.15.6961"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00014a033"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-008-8646-5"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094909"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.2002.01014.x"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.10.13.8940297"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63243-9"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12315-1"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000366389"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2019.07.033"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20174277"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-018-0137-7"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-017-0240-4"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00677-2"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0141947"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.13.4680-4690.2000"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000330699"},{"key":"e_1_3_3_19_2","first-page":"1","article-title":"Effect of acute kidney injury on long-term mortality in patients with ST-segment elevation myocardial infarction complicated by cardiogenic shock who underwent primary percutaneous coronary intervention in a high-volume tertiary center","volume":"48","author":"Hayiroglu MI","year":"2020","unstructured":"Hayiroglu MI, Bozbeyoglu E, Yildirimturk O, et al. Effect of acute kidney injury on long-term mortality in patients with ST-segment elevation myocardial infarction complicated by cardiogenic shock who underwent primary percutaneous coronary intervention in a high-volume tertiary center. Turk Kardiyol Dernegi Arsivi. 2020;48:1-9.","journal-title":"Turk Kardiyol Dernegi Arsivi"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(17)30183-3"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0201com"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.4149\/gpb_2010_04_319"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3380745"},{"key":"e_1_3_3_24_2","volume-title":"Declaration of Helsinki: ethical principles for medical research involving human subjects","author":"World Medical Association","year":"2013","unstructured":"World Medical Association. Declaration of Helsinki: ethical principles for medical research involving human subjects. Ferney-Voltaire, France: World Medical Association, https:\/\/www.wma.net\/policies-post\/wma-declaration-of-helsinki-ethical-principles-for-medical-research-involving-human-subjects\/ (2013, Accessed 02 Jan, 2022)."},{"issue":"1","key":"e_1_3_3_25_2","first-page":"12","article-title":"Directive 2001\/20\/EC of the European parliament and of the council of 4 april 2001 on the approximation of the laws, regulations and administrative provisions of the Member States relating to the implementation of good clinical practice in the conduct of clinical trials on medicinal products for human use","volume":"9","year":"2001","unstructured":"Directive 2001\/20\/EC of the European parliament and of the council of 4 april 2001 on the approximation of the laws, regulations and administrative provisions of the Member States relating to the implementation of good clinical practice in the conduct of clinical trials on medicinal products for human use. 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