{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:37:20Z","timestamp":1777401440636,"version":"3.51.4"},"reference-count":41,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:00:00Z","timestamp":1707091200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the Natural Science Foundation of Shandong Province","award":["ZR2020QH281"],"award-info":[{"award-number":["ZR2020QH281"]}]},{"name":"the Natural Science Foundation of Shandong Province","award":["ZR2021QH032"],"award-info":[{"award-number":["ZR2021QH032"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Angiology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:p>\n                    The present study aimed to investigate the balance between angiotensin II (Ang-II) and kallikrein (KLK1) in the pathogenesis of ST-segment elevation acute myocardial infarction (STEMI). The study included a total of 261 participants: 151 STEMI patients and 110 individuals with normal coronary arteries. The plasma levels of Ang-II and KLK1 were measured using enzyme-linked immunosorbent assays (ELISA). Multivariate logistic regression analysis indicated that the plasma levels of Ang-II, KLK1 and the ratio of Ang-II and KLK1 (Ang-II\/KLK1) independently correlated with the presence of STEMI. Furthermore, we found independent associations between STEMI and smoking, cholesterol (CHO), high-density lipoprotein cholesterol (HDL-c), as well as age. The ratio of Ang-II\/KLK1 correlated with the plasma level of the inflammatory cytokine, interleukin-6 (IL-6). Both Ang-II and KLK1 levels are significantly elevated in patients with STEMI. An increased Ang-II\/KLK1 ratio may result in the over-activation of Ang-II and exacerbate the progression of STEMI(\n                    <jats:italic>P<\/jats:italic>\n                    = .046). In conclusion, we have demonstrated, for the first time, an Ang-II and KLK1 imbalance in patients with STEMI.\n                  <\/jats:p>","DOI":"10.1177\/00033197241232165","type":"journal-article","created":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T19:44:17Z","timestamp":1707162257000},"page":"589-596","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Imbalance Between Angiotensin II and Kallikrein in Patients With ST-Segment Elevation Myocardial Infarction: A Case-Control Emergency Room Study"],"prefix":"10.1177","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2294-493X","authenticated-orcid":false,"given":"Shuhong","family":"Dai","sequence":"first","affiliation":[{"name":"Department of Cardiology, Zibo Central Hospital, Zibo, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zibo Central Hospital, Zibo, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Thyroid and Breast Surgery, Zibo Municipal Hospital, Zibo, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Spinal Surgery, Zibo Central Hospital, Zibo, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,2,5]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"8887248","article-title":"The role of angiotensin antagonism in coronary plaque regression: insights from the Glagovian model","volume":"2021","author":"Alkatiri AH","year":"2021","unstructured":"Alkatiri AH, Firman D, Alkatiri AA, Suryajaya PI, Sudharsono A. The role of angiotensin antagonism in coronary plaque regression: insights from the Glagovian model. Int J Vasc Med. 2021;2021:8887248.","journal-title":"Int J Vasc Med"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15454"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/1470320312474854"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2006.085"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091780"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091017"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00634-8"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2021.02.006"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13550"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1556\/1646.11.2019.20"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.11.036"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-019-4838-9"},{"key":"e_1_3_3_14_2","first-page":"32","article-title":"CRP\/albumin ratio: a promising marker of gram-negative bacteremia in late-onset neonatal sepsis","volume":"56","author":"G\u00fcne\u015f H","year":"2021","unstructured":"G\u00fcne\u015f H, Yurttutan S, \u00c7obanu\u015fa\u011f\u0131 M, Do\u011faner A. CRP\/albumin ratio: a promising marker of gram-negative bacteremia in late-onset neonatal sepsis. Turk Arch Pediatr. 2021;56:32-36.","journal-title":"Turk Arch Pediatr"},{"key":"e_1_3_3_15_2","first-page":"e29243","article-title":"Use of the C-reactive protein (CRP)\/Albumin ratio as a severity tool in acute pancreatitis: systematic review","volume":"14","author":"Tarar MY","year":"2022","unstructured":"Tarar MY, Khalid A, Choo XY, Khurshid S, Tumeh H, Muhammad K. Use of the C-reactive protein (CRP)\/Albumin ratio as a severity tool in acute pancreatitis: systematic review. Cureus. 2022;14:e29243.","journal-title":"Cureus"},{"key":"e_1_3_3_16_2","first-page":"e21833","article-title":"Evaluation of nutritional status in hospitalized chronic obstructive pulmonary disease patients and can C-reactive protein-to-albumin ratio Be used in the nutritional risk assessment in these patients","volume":"14","author":"Baldemir R","year":"2022","unstructured":"Baldemir R, \u00d6zt\u00fcrk A, Eraslan Doganay G, Cirik MO, Alagoz A. Evaluation of nutritional status in hospitalized chronic obstructive pulmonary disease patients and can C-reactive protein-to-albumin ratio Be used in the nutritional risk assessment in these patients. Cureus. 2022;14:e21833.","journal-title":"Cureus"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-021-01755-1"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn223"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200502000-00018"},{"key":"e_1_3_3_20_2","first-page":"457","article-title":"Human tissue kallikrein activity in angiographically documented chronic stable coronary artery disease","volume":"105","author":"Figueiredo EL","year":"2015","unstructured":"Figueiredo EL, Magalh\u00e3es CA, Belli KC, et al. Human tissue kallikrein activity in angiographically documented chronic stable coronary artery disease. Arq Bras Cardiol. 2015;105:457-465.","journal-title":"Arq Bras Cardiol"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH12-06-0396"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.2040-4603.2011.tb00347.x"},{"key":"e_1_3_3_23_2","first-page":"176","article-title":"Predictive and protective role of high-density lipoprotein cholesterol in acute myocardial infarction","volume":"26","author":"Park JS","year":"2019","unstructured":"Park JS, Cha KS, Lee HW, et al. Predictive and protective role of high-density lipoprotein cholesterol in acute myocardial infarction. Cardiol J. 2019;26:176-185.","journal-title":"Cardiol J"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.01067"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2016-0619"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2006.17.206"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.58.5.908"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22404"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2013.04.017"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2014.12.003"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.34172\/jcvtr.2022.28"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2015.01.007"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a062124"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1645-8"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073035"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2013.11.014"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2006.085"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201903149R"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0b013e32834d54b1"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2022.03.016"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.107179"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088894"}],"container-title":["Angiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00033197241232165","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00033197241232165","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00033197241232165","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:21:56Z","timestamp":1777371716000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00033197241232165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,5]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1177\/00033197241232165"],"URL":"https:\/\/doi.org\/10.1177\/00033197241232165","relation":{},"ISSN":["0003-3197","1940-1574"],"issn-type":[{"value":"0003-3197","type":"print"},{"value":"1940-1574","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,5]]}}}