{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T15:46:31Z","timestamp":1780415191080,"version":"3.54.1"},"reference-count":35,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Angiology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:p>Contrast-induced nephropathy (CIN) poses a significant risk following primary percutaneous coronary intervention (pPCI) in patients with ST-Elevation Myocardial Infarction (STEMI). Magnesium (Mg\u00b2\u207a) deficiency has been associated with renal dysfunction and cardiovascular diseases, yet its role in CIN development remains unclear. This study represents the first investigation exploring the relationship between Mg\u00b2\u207a levels and CIN in this context.<\/jats:p>\n                  <jats:p>\n                    We conducted a retrospective study involving 2306 consecutive STEMI patients undergoing pPCI. Serum Mg\u00b2\u207a levels were measured on admission. Logistic regression and Receiver Operating Characteristic (ROC) analysis were employed to assess the association between Mg\u00b2\u207a levels and CIN development. Of the enrolled patients, 691 (30%) developed CIN post-pPCI. Mg\u00b2\u207a levels were significantly lower in the CIN group (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.001). Multivariate analysis identified Mg\u00b2\u207a &lt;2.03\u2009mg\/dL, age &gt;68\u2009years, left ventricular Ejection Fraction (EF) &lt;49%, and post-procedure Thrombolysis In Myocardial Infarction (TIMI) flow grade &lt;2 as independent predictors of CIN. ROC analysis revealed an Mg\u00b2\u207a cutoff of 2.03\u2009mg\/dL, Area Under the Curve (AUC): 0.711, sensitivity: 69%, specificity: 68%). Our study demonstrates a significant correlation between low Mg\u00b2\u207a levels and CIN in STEMI patients undergoing pPCI, highlighting Mg\u00b2\u207a &lt;2.03\u2009mg\/dL as an independent risk factor for CIN.\n                  <\/jats:p>","DOI":"10.1177\/00033197251314629","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T04:38:01Z","timestamp":1737520681000},"page":"572-579","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["The Role of Magnesium Levels in the Progression of Contrast-Induced Nephropathy in Patients With STEMI Undergoing Primary PCI"],"prefix":"10.1177","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4846-0770","authenticated-orcid":false,"given":"Ay\u015fe \u0130rem","family":"Demirtola","sequence":"first","affiliation":[{"name":"Department of Cardiology, University of Health Sciences Ankara City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anar","family":"Mammadli","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Bay\u0131nd\u0131r Sogutozu Hospital Ankara, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6khan","family":"\u00c7i\u00e7ek","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Health Sciences Ankara City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,1,22]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2017-311975"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000368"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfab212"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11082167"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000339789"},{"key":"e_1_3_3_7_2","article-title":"A European Renal Best Practice (ERBP) position statement on the Kidney Disease Improving Global Outcomes (KDIGO) clinical practice guidelines on acute kidney injury: part 1: definitions, conservative management and contrast-induced nephropathy","volume":"27","author":"Fliser D","year":"2012","unstructured":"Fliser D, Laville M, Covic A, et al. A European Renal Best Practice (ERBP) position statement on the Kidney Disease Improving Global Outcomes (KDIGO) clinical practice guidelines on acute kidney injury: part 1: definitions, conservative management and contrast-induced nephropathy. Nephrol Dial Transplant. 2012;27:4263-72.","journal-title":"Nephrol Dial Transplant"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.203.3.9169676"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000016043.87291.33"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.07.043"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3934\/publichealth.2016.2.329"},{"key":"e_1_3_3_12_2","article-title":"Magnesium and kidney health\u2014more on the \u201cforgotten electrolyte","volume":"44","author":"Vormann J.","year":"2016","unstructured":"Vormann J. Magnesium and kidney health\u2014more on the \u201cforgotten electrolyte.\u201d Am J Nephrol. 2016;44:379-80.","journal-title":"\u201d Am J Nephrol"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-022-03118-3"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-020-02168-x"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19030664"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2006.077180"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/10815589231182317"},{"key":"e_1_3_3_18_2","article-title":"Contrast material-induced renal failure in patients with diabetes mellitus, renal insufficiency, or both","volume":"320","author":"Parfrey PS","year":"2010","unstructured":"Parfrey PS, Griffiths SM, Barrett BJ, et al. Contrast material-induced renal failure in patients with diabetes mellitus, renal insufficiency, or both. 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