{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:40:26Z","timestamp":1777401626466,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Angiology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:p>\n                    Patients with chronic-limb threatening ischemia (CLTI) and peripheral wounds might be predisposed for systemic infections. The study aimed to describe the rate of systemic infections in patients with CLTI compared with peripheral artery obstructive disease (PAOD) patients without CLTI, both independently of endovascular treatment (EVT) and after EVT. Administrative data of the AOK Baden-Wuerttemberg (AOK BW) from patients with PAOD were analyzed considering bloodstream infection (BSI), 30-day readmission and prescribed antibiotics for ischemic ulcers. The risk of BSI increased 3.9-fold (95% CI: 3.4\u20134.4) in patients with PAOD Rutherford-Becker category (RBC) 5 and 6 (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200911,741) compared with PAOD RBC 1-4 (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200923,482; 6.81% vs 1.67%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.01). The risk of\n                    <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                    BSI increased 5.6-fold (95% CI: 4.1\u20137.7) comparing RBC 5 and 6 (1.2%) with RBC 1-4 (0.22%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.01). Outpatient antibiotic prescriptions were dominated by aminopenicillins with \u03b2-lactamase inhibitors, accounting for 34.9%. Clindamycin, cefuroxime, and fluoroquinolones represented 14.9%, 13.5%, and 12.6% of prescriptions, respectively. Infections were responsible for 7.7% of 30-day readmissions following EVT. Patients with CLTI are at risk of developing BSI, and specifically\n                    <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                    BSI. Infection-related causes in 30-day readmissions following EVT are common. The high use of clindamycin and cefuroxime in outpatients is concerning.\n                  <\/jats:p>","DOI":"10.1177\/00033197251319600","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T03:52:32Z","timestamp":1739505152000},"page":"315-320","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Antibiotic Consumption and Bloodstream Infections in Patients With Chronic-limb Threatening Ischemia Following Endovascular Therapy in East-west Germany, 2019\u20132020"],"prefix":"10.1177","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9841-3417","authenticated-orcid":false,"given":"Jonas","family":"Salm","sequence":"first","affiliation":[{"name":"Department of Cardiology and Angiology, University Heart Center Freiburg - Bad Krozingen, Medical Center \u2013Faculty of Medicine, University of Freiburg, Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9633-0351","authenticated-orcid":false,"given":"Valeska","family":"Hofbauer-Milan","sequence":"additional","affiliation":[{"name":"AOK Baden-Wuerttemberg, Department of Data Analytics and Data Science, Stuttgart, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"W\u00fcstholz","sequence":"additional","affiliation":[{"name":"AOK Baden-Wuerttemberg, Department of Data Analytics and Data Science, Stuttgart, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olaf","family":"Schneider","sequence":"additional","affiliation":[{"name":"AOK Baden-Wuerttemberg, Department of Data Analytics and Data Science, Stuttgart, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Westermann","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology, University Heart Center Freiburg - Bad Krozingen, Medical Center \u2013Faculty of Medicine, University of Freiburg, Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Zeller","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology, University Heart Center Freiburg - Bad Krozingen, Medical Center \u2013Faculty of Medicine, University of Freiburg, Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,2,14]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(23)00355-8"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.02.040"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv006"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2016.09.055"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.120.006550"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2013.08.003"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00462-2"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2207899"},{"key":"e_1_3_3_10_2","unstructured":"Medizinische Dienste in Deutschland Medizinischer Dienst Bund mit Sitz in Essen."},{"key":"e_1_3_3_11_2","article-title":"Diabetes mellitus and bacteraemia: a comparative study between diabetic and non-diabetic patients","volume":"1","author":"Carton JA","year":"1992","unstructured":"Carton JA, Maradona JA, Nu\u00f1o FJ, et al. Diabetes mellitus and bacteraemia: a comparative study between diabetic and non-diabetic patients. Eur J Med. 1992;1:281-7.","journal-title":"Eur J Med"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199912163412507"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5520(05)70153-7"},{"key":"e_1_3_3_14_2","article-title":"The role of diabetes mellitus in patients with bloodstream infections","volume":"138","author":"Stoeckle M","year":"2008","unstructured":"Stoeckle M, Kaech C, Trampuz A, et al. The role of diabetes mellitus in patients with bloodstream infections. Swiss Med Wkly. 2008;138:512-9.","journal-title":"Swiss Med Wkly"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0290103"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1024\/0301-1526\/a000831"},{"key":"e_1_3_3_17_2","article-title":"Readmissions after revascularization procedures for peripheral arterial disease","volume":"168","author":"Secemsky EA","year":"2017","unstructured":"Secemsky EA, Schermerhorn M, Carroll BJ, et al. Readmissions after revascularization procedures for peripheral arterial disease. Ann Intern Med. 2017;168:93-9.","journal-title":"Ann Intern Med"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/13.2.191"},{"key":"e_1_3_3_19_2","first-page":"70","article-title":"GKV-Routinedaten in der onkologischen Versorgungsforschung","volume":"2018","author":"Geyer S","year":"2018","unstructured":"Geyer S, Kowalski C. GKV-Routinedaten in der onkologischen Versorgungsforschung. 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