{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:41:19Z","timestamp":1789760479903,"version":"4.0.1"},"reference-count":43,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100005788","name":"Medical University Vienna","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005788","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Angiology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:p>\n                    Atherosclerotic peripheral artery disease (PAD) and chronic kidney disease (CKD) are highly interconnected diseases, while causes for excess mortality are not well-defined. Fibroblast growth-factor 23 (FGF-23) is elevated in mineral bone disease of CKD and was shown to be associated with higher mortality. However, it is not known if this association extends to PAD. FGF-23 was measured by ELISA in serum samples of 298 patients with stable PAD (Fontaine stage I-II) with an estimated glomerular filtration rate (eGFR) of 72 (58\u201385) ml\/min. Mortality was assessed after a long-term follow-up of up to 10\u2009years. FGF-23 showed significant associations with markers of metabolic syndrome (triglycerides\n                    <jats:italic toggle=\"yes\">r<\/jats:italic>\n                    \u2009=\u2009.25,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.001, high-density lipoprotein cholesterol (HDL-C) r\u2009=\u2009\u2212.28,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.001, c-reactive protein (CRP)\n                    <jats:italic toggle=\"yes\">r<\/jats:italic>\n                    \u2009=\u2009.14,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.016). Multivariable Cox-regression outcome analyses showed significant associations between FGF-23 and all-cause mortality (hazard ratio 1.35, 95% confidence interval 1.05\u20131.74) in PAD patients even after adjustment for traditional cardiovascular risk factors and renal excretory function. FGF-23 is associated with higher mortality in patients with PAD. Our findings indicate that FGF-23 has detrimental effects on patients with PAD that are independent of renal excretory function.\n                  <\/jats:p>","DOI":"10.1177\/00033197251326637","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:27:45Z","timestamp":1747787265000},"page":"630-636","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["FGF-23 and Long-term Outcome in Peripheral Artery Disease"],"prefix":"10.1177","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3225-9063","authenticated-orcid":false,"given":"Bernhard","family":"Zierfuss","sequence":"first","affiliation":[{"name":"Division of Angiology, Medicine II, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marija","family":"Bojic","sequence":"additional","affiliation":[{"name":"1st Medical Department, Hanusch Hospital, Vienna, Austria"},{"name":"Division of Nephrology and Dialysis, Medicine III, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerit-Holger","family":"Schernthaner","sequence":"additional","affiliation":[{"name":"Division of Angiology, Medicine II, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9704-1452","authenticated-orcid":false,"given":"Clemens","family":"H\u00f6baus","sequence":"additional","affiliation":[{"name":"Division of Angiology, Medicine II, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,5,20]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl092"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1615664"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1801174"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1812389"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504720"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14700"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2019.09.012"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2016.11.012"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.553198"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005010052"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2004.09.007"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M408903200"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2007.00308.x"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00328.x"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2018.08.039"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.5301\/JN.2010.5818"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-017-0559-x"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2016.1241428"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae179"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc24-S009"},{"key":"e_1_3_3_22_2","unstructured":"World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. 2024 [cited 2025 Feb 9]. 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