{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:33:59Z","timestamp":1792787639686,"version":"4.5.0"},"reference-count":49,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T00:00:00Z","timestamp":1748044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Guangdong Provincial\u2019s Hospital","award":["KH012023350"],"award-info":[{"award-number":["KH012023350"]}]},{"name":"National Science Foundation for Young Scientist of China","award":["No. 82070360"],"award-info":[{"award-number":["No. 82070360"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Angiology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:p>\n                    Chronic kidney disease (CKD) is a complex disease that may exacerbate the inflammatory state in patients with coronary artery disease (CAD). The predictive value of the Aggregate Index of Systemic Inflammation (AISI) for individuals with CAD and chronic kidney disease (CKD) remains unclear. The data for this study were obtained from the Cardiorenal Improvement II (CIN-II) cohort. Patients (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200915,133) with CAD combined with CKD were included. The AISI was calculated using the formula: neutrophil*platelet*monocyte\/lymphocyte counts. During a median follow-up of 4.26\u2009years, 3979 deaths occurred, including 2239 cardiovascular (CV) deaths. With adjustment for potential confounding factors, the level of AISI was associated with a higher risk of all-cause mortality (Q [quartile]2, Q3, Q4: hazard ratio [HR] [95 CI%]\u2009=\u20091.20 [1.09\u20131.32], 1.34 [1.22\u20131.48], and 1.59 [1.44\u20131.75], respectively; p\n                    <jats:sub>trend<\/jats:sub>\n                    \u2009&lt;\u20090.001) and CV mortality (Q2, Q3, Q4: HR [95 CI%]\u2009=\u20091.27 [1.11\u20131.45], 1.50 [1.32\u20131.71], 1.78 [1.55\u20132.03], respectively; p\n                    <jats:sub>trend<\/jats:sub>\n                    \u2009&lt;\u20090.001). Elevated AISI level was independently associated with increased risks of all-cause and CV-specific mortality in patients with CAD and CKD.\n                  <\/jats:p>","DOI":"10.1177\/00033197251338428","type":"journal-article","created":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T00:01:12Z","timestamp":1748131272000},"page":"752-761","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Relationship Between the Aggregate Index of Systemic Inflammation and the prognosis in Patients With CAD and CKD"],"prefix":"10.1177","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3046-1820","authenticated-orcid":false,"given":"Tian","family":"Chang","sequence":"first","affiliation":[{"name":"School of Medicine, South China University of Technology, Guangzhou, China"},{"name":"Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3777-9516","authenticated-orcid":false,"given":"Yibo","family":"He","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China"},{"name":"Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihang","family":"Ling","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyou","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Medicine, South China University of Technology, Guangzhou, China"},{"name":"Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China"},{"name":"Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linfang","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianlin","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeliang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6638-2334","authenticated-orcid":false,"given":"Jin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China"},{"name":"Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyan","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Medicine, South China University of Technology, Guangzhou, China"},{"name":"Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,5,24]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"902","article-title":"Guidelines for the early evaluation and management of chronic kidney disease in China","volume":"62","author":"Chinese Preventive Medicine Association for Kidney Disease","year":"2023","unstructured":"Chinese Preventive Medicine Association for Kidney Disease. Guidelines for the early evaluation and management of chronic kidney disease in China. Zhonghua Nei Ke Za Zhi. 2023;62:902-930.","journal-title":"Zhonghua Nei Ke Za Zhi"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30045-3"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.04.052"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2022.6817"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-11-117"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu299"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.26111"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S283835"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S426961"},{"key":"e_1_3_2_11_2","article-title":"The relationship between the systemic immune-inflammation index and ischemia with non-obstructive coronary arteries in patients undergoing coronary angiography","volume":"121","author":"Karakayali M","year":"2024","unstructured":"Karakayali M, Altunova M, Yakisan T, et al. The relationship between the systemic immune-inflammation index and ischemia with non-obstructive coronary arteries in patients undergoing coronary angiography. Arq Bras Cardiol. 2024;121:e20230540.","journal-title":"Arq Bras Cardiol"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14112675"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110805"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-020-0894-7"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1163900"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.774365"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S462848"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-022-01659-y"},{"key":"e_1_3_2_20_2","doi-asserted-by":"crossref","DOI":"10.1007\/s11135-006-9018-6","article-title":"A caution regarding rules of thumb for variance inflation factors","volume":"41","author":"O\u2019brien RM.","year":"2007","unstructured":"O\u2019brien RM. 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