{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T23:06:22Z","timestamp":1788822382587,"version":"build-2803163510"},"reference-count":49,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Health and Medical Research Project of Anhui Provincial Health Commission","award":["AHWJ2023A20458"],"award-info":[{"award-number":["AHWJ2023A20458"]}]},{"name":"Doctor Special Fund of the Second People\u2019s Hospital of Hefei","award":["2022bszx10"],"award-info":[{"award-number":["2022bszx10"]}]},{"name":"the Key Scientific Research Foundation of the Education Department of the Province Anhui","award":["2023AH050653"],"award-info":[{"award-number":["2023AH050653"]}]},{"name":"Institutional Research Fund Project of the Second People\u2019s Hospital of Hefei","award":["2024ykc02"],"award-info":[{"award-number":["2024ykc02"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Angiology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>\n                    This study aimed to compare carotid atherosclerotic indicators among patients with newly diagnosed type 2 diabetes mellitus (NT2DM), pre-diabetes mellitus (PDM), and healthy controls (HCs), and to investigate associations between nonalcoholic fatty liver disease (NAFLD) and carotid atherosclerosis. A total of 240 participants were enrolled (120 NT2DM, 60 PDM, and 60 HCs). Liver fat content (LFC) was assessed using proton magnetic resonance spectroscopy ([\n                    <jats:sup>1<\/jats:sup>\n                    H]-MRS). Carotid intima-media thickness (CIMT) and carotid pulse wave velocity (PWV) at the beginning (BS-PWV) and end of systole (ES-PWV) were measured by ultrasonography. The levels of LFC were significantly higher in NT2DM (14.57%\u2009\u00b1\u20096.49%) and PDM (11.44%\u2009\u00b1\u20095.62%) than in HCs (5.73%\u2009\u00b1\u20094.08%;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    =.000). The prevalence of NAFLD was 66.7% in NT2DM, 38.3% in PDM, and 25.0% in HCs. CIMT, BS-PWV, and ES-PWV were significantly elevated in NT2DM compared with PDM and HCs (all\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.05). Multiple linear regression (MLR) analyses showed LFC and triglycerides were strong contributors to both BS-PWV and ES-PWV. Elevated LFC and NAFLD prevalence in NT2DM, together with their associations with carotid atherosclerosis, suggest a potential link between NAFLD and cardiovascular disease in T2DM.\n                  <\/jats:p>","DOI":"10.1177\/00033197251384344","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T08:23:11Z","timestamp":1762417391000},"page":"1007-1015","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of Liver Fat Content With Carotid Endothelial Function in Patients With Newly Diagnosed Type 2 Diabetes Mellitus and Pre-Diabetes Mellitus"],"prefix":"10.1177","volume":"77","author":[{"given":"Yan","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Ultrasound, The Second People\u2019s Hospital of Hefei, The Affiliated Hefei Hospital, Anhui Medical University, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Sheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Second People\u2019s Hospital of Hefei, The Affiliated Hefei Hospital, Anhui Medical University, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui-Ping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, The Second People\u2019s Hospital of Hefei, The Affiliated Hefei Hospital, Anhui Medical University, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, The Second People\u2019s Hospital of Hefei, The Affiliated Hefei Hospital, Anhui Medical University, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Xiang","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Magnetic Resonance Imaging, The Second People\u2019s Hospital of Hefei, The Affiliated Hefei Hospital, Anhui Medical University, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Lian","sequence":"additional","affiliation":[{"name":"Department of Magnetic Resonance Imaging, The Second People\u2019s Hospital of Hefei, The Affiliated Hefei Hospital, Anhui Medical University, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Hong","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Second People\u2019s Hospital of Hefei, The Affiliated Hefei Hospital, Anhui Medical University, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Second People\u2019s Hospital of Hefei, The Affiliated Hefei Hospital, Anhui Medical University, Anhui, 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