{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:43:38Z","timestamp":1777401818814,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Angiology"],"abstract":"<jats:p>\n                    Sickle cell disease (SCD) leads to red blood cell deformities resulting in vaso-occlusion and multiorgan damage. Outcomes and adverse prognosticators among SCD patients with cardiovascular and thromboembolic (CVTE) complications are not well established. Therefore, we aimed to assess characteristics, outcomes, and mortality predictors for hospitalized SCD patients with CVTE complications. The National Inpatient Sample (2012-2021) was queried using ICD-9 and -10 codes for CVTE complications and relevant data in SCD patients. Mortality trends were examined with the Cochran-Armitage test, and factors associated with mortality were identified with multivariable logistic regression accounting for the weighted survey design. There were 1\u2009388\u2009310 SCD-related hospitalizations (mean age 31.3\u2009\u00b1\u20090.1\u2009years; 56.4% female), of which 441\u2009820 (31.8%) involved CVTE complications, including deep vein thrombosis (33.6%), pulmonary embolism (27%), acute chest syndrome (26%), congestive heart failure (21.3%), and pulmonary hypertension (18.2%). In-hospital mortality was higher in patients with CVTE complications (1.5% vs 0.3%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.0001). Charlson comorbidity index, myocardial infarction, arrhythmias, stroke, pulmonary embolism, and COVID-19 infection were identified as predictors of inpatient mortality. In conclusion, CVTE complications are associated with increased inpatient mortality. Early recognition of mortality predictors may support more effective risk stratification and timely interventions.\n                  <\/jats:p>","DOI":"10.1177\/00033197261418309","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T06:25:03Z","timestamp":1772000703000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Contemporary Trends, In-Hospital Outcomes, and Adverse Prognosticators of Sickle Cell Patients with Cardiovascular and Thromboembolic Complications: A National Database Analysis"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5285-4897","authenticated-orcid":false,"given":"Harsha","family":"Sanaka","sequence":"first","affiliation":[{"name":"Section of Cardiovascular Imaging, Robert and Suzanne Tomsich Department of Cardiovascular Medicine, Sydell and Arnold Miller Family Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin-I","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Statistics, Actuarial &amp; Data Sciences, Central Michigan University, Mount Pleasant, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elio","family":"Haroun","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Imaging, Robert and Suzanne Tomsich Department of Cardiovascular Medicine, Sydell and Arnold Miller Family Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7885-6667","authenticated-orcid":false,"given":"Ankit","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Imaging, Robert and Suzanne Tomsich Department of Cardiovascular Medicine, Sydell and Arnold Miller Family Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aro Daniela","family":"Arockiam","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Imaging, Robert and Suzanne Tomsich Department of Cardiovascular Medicine, Sydell and Arnold Miller Family Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5570-9402","authenticated-orcid":false,"given":"Tom Kai Ming","family":"Wang","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Imaging, Robert and Suzanne Tomsich Department of Cardiovascular Medicine, Sydell and Arnold Miller Family Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21570"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000035237"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022009202"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199406093302303"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27279"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1903212"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1715971"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1611770"},{"key":"e_1_3_2_10_2","unstructured":"Bartelt K Sandberg N Franklin B Deckert J. Sickle cell patients are living a decade longer in 2022 than in 2008. Epic Research. 2023. Accessed December 30 2025. https:\/\/epicresearch.org\/articles\/sickle-cell-patients-are-living-a-decade-longer-in-2022-than-in-2008"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21569"},{"key":"e_1_3_2_12_2","article-title":"In-hospital outcomes and characteristics of heart failure in sickle cell disease","volume":"11","author":"Fadiran O","year":"2019","unstructured":"Fadiran O, Balogun AF, Ogunti R, et al. In-hospital outcomes and characteristics of heart failure in sickle cell disease. 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