{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T22:28:49Z","timestamp":1792276129296,"version":"4.4.0"},"reference-count":42,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Angiology"],"abstract":"<jats:p>\n                    Acute stent thrombosis (ST) after primary percutaneous coronary intervention (pPCI) for ST-segment elevation myocardial infarction (STEMI) is uncommon but often fatal. We evaluated whether the Aggregate Index of Systwemic Inflammation (AISI) predicts acute ST and in-hospital mortality. In this retrospective cohort, 3055 consecutive STEMI patients underwent pPCI with stent implantation. Admission AISI was calculated as (neutrophils\u2009\u00d7\u2009monocytes\u2009\u00d7\u2009platelets)\/lymphocytes. Multivariable logistic regression identified independent predictors; receiver operating characteristic (ROC) analysis assessed discrimination for acute ST. Acute ST occurred in 76 patients (2.5%) and was associated with higher in-hospital mortality (15.8% vs 3.8%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.001). AISI was higher in patients with acute ST (1314.2 vs 689.7,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.001) and independently predicted acute ST (OR 1.03, 95% CI 1.02-1.05). AISI showed moderate discrimination area under the curve (AUC) 0.720; cut-off 904.97; sensitivity 64.2%; specificity 64.3%). Higher AISI was also independently associated with in-hospital mortality (OR 1.05,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.001). Admission AISI is independently associated with acute ST and early death after pPCI for STEMI, supporting its use as a rapid, low-cost risk marker pending prospective validation.\n                  <\/jats:p>","DOI":"10.1177\/00033197261456795","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T07:28:21Z","timestamp":1780385301000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Aggregate Index of Systemic Inflammation as a Predictor of Acute Stent Thrombosis in STEMI Undergoing Primary PCI"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7977-1785","authenticated-orcid":false,"given":"Mehmet Taha","family":"\u00d6zkan","sequence":"first","affiliation":[{"name":"Department of Cardiology, Ankara Etlik City Hospital, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7193-4324","authenticated-orcid":false,"given":"Veysel Ozan","family":"Tan\u0131k","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ankara Etlik City Hospital, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1696-7449","authenticated-orcid":false,"given":"Alperen","family":"Ta\u015f","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ahi Evran University Training and Research Hospital, K\u0131r\u015fehir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0911-1271","authenticated-orcid":false,"given":"Muhammed","family":"Erzurum","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, Karab\u00fck University, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7111-8450","authenticated-orcid":false,"given":"\u00c7a\u011fatay","family":"Tunca","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ankara Etlik City Hospital, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etkin","family":"Elifo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ankara Etlik City Hospital, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sena","family":"Tokatl\u0131","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ankara Etlik City Hospital, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5429-1323","authenticated-orcid":false,"given":"B\u00fclent","family":"\u00d6zlek","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, Mu\u011fla University, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.11.087"},{"key":"e_1_3_3_3_2","first-page":"1","article-title":"Deaths: final data for 2017","volume":"68","author":"Kochanek KD","year":"2019","unstructured":"Kochanek KD, Murphy SL, Xu J, et al. 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